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DNA Polymerase Delta Catalytic Subunit

Known as: POLD1, CDC2 Homolog, EC 2.7.7.7 
DNA polymerase delta catalytic subunit (1107 aa, ~124 kDa) is encoded by the human POLD1 gene. This protein is involved in both DNA leading strand… 
National Institutes of Health

Related topics

Related topics

14 relations
Cell NucleusDNA Polymerase IIIDNA ReplicationDNA Replication Proofreading

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Abstract 2724: A combination of short-read and long-read RNA sequencing reveals NOVA1’s role in telomere biology
Dysregulated alternative splicing underlies many aspects of cancer cell biology including tumor cell telomere maintenance. We… 
2019
2019
Reply to: “Development of an MSI-positive colon tumor with aberrant DNA methylation in a PPAP patient”
Yamaguchi et al. [1] identified a germline frameshift variant in the POLE gene, c.4191_4192delCT (p.Tyr1398*), located outside… 
2018
2018
Silicon Coordinates DNA Replication with Transcription of the Replisome Factors in Diatom Algae
Transcription is a key in coordinating the action of actors involved in DNA replication. The present research characterizes the… 
2018
2018
534P Patterns of germline and somatic mutations in 16 mismatch repair associated genes analyzed with next generation sequencing (NGS) in colorectal cancer with EMAST (1) and/or MSI-high
Results: Totally 284 pathological germline mutations were identified in 161 patients with MSI-high or EMASTþ. The most common… 
2018
2018
Abstract 4335: High incidence ofPOLEandPOLD1mutations in Chinese colorectal cancer patients identified by comprehensive genomic profiling
Introduction: The proofreading 39-59 exonuclease activities of DNA polymerase-e (POLE) and δ (POLD1) are critical for preventing… 
2017
2017
POLD replicates both strands of small kilobase-long replication bubbles initiated at a majority of human replication origins
Error-prone mutants of polymerase epsilon (POLE*) or polymerase delta (POLD1*) induce a mutator phenotype in human cancers. Here… 
1995
1995
Structure of the gene for the catalytic subunit of human DNA polymerase delta (POLD1).
We have isolated genomic DNA clones covering the gene for human DNA polymerase delta catalytic subunit (POLD1) and its 5… 
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