PNC-27
National Institutes of Health
Papers overview
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The E3 ligase human double minute 2 (HDM2) regulates the activity of the tumor suppressor protein p53. A p53-independent HDM2…
Objectives. Paclitaxel is widely used in the treatment of gynecologic malignancies. It targets tumor cells in the M phase of the…
OBJECTIVE
Despite an 80% response rate to chemotherapy, epithelial ovarian cancer has the highest case fatality rate of all…
GOALS
We have developed the anti-cancer peptide, PNC-27, which is a membrane-active peptide that binds to the HDM-2 protein…
The anticancer peptide PNC-27, which contains an HDM-2-binding domain corresponding to residues 12-26 of p53 and a transmembrane…
PurposePNC-27, a peptide that contains an HDM-2-binding domain from p53 attached to a membrane-penetrating peptide on its…
In vivo and in vitro studies have shown the efficiency of anti-cancer peptides PNC-27 and PNC-28 in killing cancer cells by…
LB-195 We have previously shown that two novel peptides, PNC-27 and PNC-28, that contain p53 hdm2 binding domain sequences 12-26…
PNC-27, a synthetic peptide, is derived from the TP53-HDM2 binding domain that include TP53 amino acids 12-26 linked with 17…
We have recently found that a peptide from the mdm-2 binding domain of the p53 protein induced rapid membranolytic necrosis of a…