Protein p53

Known as: Tumor Protein p53, p53 proteins, Tumor Suppressor Protein p53 [Chemical/Ingredient] 
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent… (More)
National Institutes of Health

Related topics

Related topics

49 relations
3'-5'-ExonucleasesATM Signaling PathwayAdrenocortical carcinomaAging
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Narrower (3)

CEP-1 protein, C elegansPNC-27PNC-28

Broader (2)

Tumor Suppressor Proteinsp53 gene/protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy.
Tumor suppressor p53 plays a central role in tumor suppression. p53 is the most frequently mutated gene in human cancer, and over… (More)
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Highly Cited
2007
Highly Cited
2007
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis.
The p53 tumor suppressor protein is a critical regulator of the cellular response to cancer-initiating insults such as genotoxic… (More)
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Highly Cited
2004
Highly Cited
2004
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
MDM2 binds the p53 tumor suppressor protein with high affinity and negatively modulates its transcriptional activity and… (More)
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Highly Cited
2001
Highly Cited
2001
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
DNA damage-induced acetylation of p53 protein leads to its activation and either growth arrest or apoptosis. We show here that… (More)
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Review
1997
Review
1997
p53, the Cellular Gatekeeper for Growth and Division
These results clearly point out that p53 uses a hyThe p53 gene and its protein product have become the drophobic interface in its… (More)
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Highly Cited
1997
Highly Cited
1997
Regulation of p53 stability by Mdm2
The tumour-suppressor p53 is a short-lived protein that is maintained at low, often undetectable, levels in normal cells… (More)
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Highly Cited
1995
Highly Cited
1995
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
The bax gene promoter region contains four motifs with homology to consensus p53-binding sites. In cotransfection assays using… (More)
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Highly Cited
1993
Highly Cited
1993
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
The ubiquitin-dependent proteolytic pathway plays a major role in selective protein degradation. Ubiquitination of proteins… (More)
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Highly Cited
1992
Highly Cited
1992
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.
A cellular phosphoprotein with an apparent molecular mass of 90 kd (p90) that forms a complex with both mutant and wild-type p53… (More)
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Highly Cited
1991
Highly Cited
1991
Participation of p53 protein in the cellular response to DNA damage.
The inhibition of replicative DNA synthesis that follows DNA damage may be critical for avoiding genetic lesions that could… (More)
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