Protein p53

Known as: Tumor Protein p53, p53 proteins, Tumor Suppressor Protein p53 [Chemical/Ingredient] 
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Tumor suppressor p53 plays a central role in tumor suppression. p53 is the most frequently mutated gene in human cancer, and over… (More)
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Highly Cited
2007
Highly Cited
2007
The p53 tumor suppressor protein is a critical regulator of the cellular response to cancer-initiating insults such as genotoxic… (More)
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Highly Cited
2004
Highly Cited
2004
MDM2 binds the p53 tumor suppressor protein with high affinity and negatively modulates its transcriptional activity and… (More)
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Highly Cited
2001
Highly Cited
2001
DNA damage-induced acetylation of p53 protein leads to its activation and either growth arrest or apoptosis. We show here that… (More)
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Review
1997
Review
1997
These results clearly point out that p53 uses a hyThe p53 gene and its protein product have become the drophobic interface in its… (More)
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Highly Cited
1997
Highly Cited
1997
The tumour-suppressor p53 is a short-lived protein that is maintained at low, often undetectable, levels in normal cells… (More)
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Highly Cited
1995
Highly Cited
1995
The bax gene promoter region contains four motifs with homology to consensus p53-binding sites. In cotransfection assays using… (More)
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Highly Cited
1993
Highly Cited
1993
The ubiquitin-dependent proteolytic pathway plays a major role in selective protein degradation. Ubiquitination of proteins… (More)
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Highly Cited
1992
Highly Cited
1992
A cellular phosphoprotein with an apparent molecular mass of 90 kd (p90) that forms a complex with both mutant and wild-type p53… (More)
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Highly Cited
1991
Highly Cited
1991
The inhibition of replicative DNA synthesis that follows DNA damage may be critical for avoiding genetic lesions that could… (More)
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