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PMX 464

Known as: PMX-464, PMX464 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2016
012320062016

Related topics

Related topics

2 relations

Broader (2)

BenzothiazolesHydroquinones

Related mentions per year

Related mentions per year

1947-2018
19401960198020002020
PMX 464
Benzothiazoles
Hydroquinones

Papers overview

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2016
2016
Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation
Thioredoxin (Trx) is an oxidoreductase with important physiological function. Imbalances in the NADPH/thioredoxin reductase… (More)
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2011
2011
Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism*
Better drugs are urgently needed for the treatment of African sleeping sickness. We tested a series of promising anticancer… (More)
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2011
2011
Structure of Mycobacterium tuberculosis thioredoxin in complex with quinol inhibitor PMX464.
Thioredoxin (Trx) plays a critical role in the regulation of cellular redox homeostasis. Many disease causing pathogens rely on… (More)
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2010
2010
Heteroaromatic 4-arylquinols are novel inducers of nuclear factor-erythroid 2-related factor 2 (Nrf2).
The induction of phase 2 and antioxidant enzymes via the transcription factor Nuclear factor-erythroid 2-related factor 2 (Nrf2… (More)
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2009
2009
The Induction of Phase 2 Response in Chemoprevention by Heteraromatic Quinols
  • Wong P.W, Yong Loo Lin
  • 2009
Cancer chemoprevention has gained more and more attention over the past 25 years and has been successful in many in vitro and in… (More)
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2008
2008
PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells
BACKGROUND AND PURPOSE Subtle changes in the intracellular reduction-oxidation (redox) state can modulate nuclear factor-kappaB… (More)
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Review
2008
Review
2008
The thioredoxin system: a key target in tumour and endothelial cells.
Thioredoxin is a redox-sensitive molecule that has pleiotropic cellular effects, such as the control of proliferation, redox… (More)
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2008
2008
Targeting airway inflammation: PMX464 and the epithelial bulls eye.
Increasing evidence places the epithelial cell at the centre of inflammatory processes in human airways. Crucial to this function… (More)
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2007
2007
A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines.
BACKGROUND AND PURPOSE PMX464 is a novel benzothiazole substituted cyclohexadienone reportedly targeting the thioredoxin (Trx1… (More)
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2006
2006
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').
The synthesis and in vitro antitumour evaluation of a new series of fluorinated benzothiazole-substituted 4-hydroxycyclohexa-2,5… (More)
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