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PMX 464

Known as: PMX-464, PMX464 
National Institutes of Health

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2 relations

Broader (2)

BenzothiazolesHydroquinones

Papers overview

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2011
2011
Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism*
Better drugs are urgently needed for the treatment of African sleeping sickness. We tested a series of promising anticancer… 
2010
2010
Mechanisms of polymyxin B endotoxin removal from extracorporeal blood flow: molecular interactions.
The outer leaflet of Gram-negative bacteria membrane contains a great amount of lipopolysaccharides, also known as endotoxins… 
2008
2008
PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells
Subtle changes in the intracellular reduction–oxidation (redox) state can modulate nuclear factor‐κB (NF‐κB) activity… 
2002
2002
Removal of endotoxin in blood by polymyxin B immobilized polystyrene-derivative fiber.
Polymyxin B, a cationic cyclic decapeptide antibiotic, is well known to bind endotoxin and to neutralize its toxicity. Based on… 
2000
2000
A new treatment for endotoxemia with direct hemoperfusion by polymyxin immobilized fiber. 1984.
:Guest Editor's Introduction: Endotoxins, which consist of lipopolysaccharides (LPS), are known to be a pathogenic substance in… 
1998
1998
Effect of hemoperfusion with polymyxin B-immobilized fiber on plasma endothelin-1 and endothelin-1 mRNA in monocytes from patients with sepsis.
1998
1998
Hemoperfusion with Polymyxin B- Immobilized Fiber Attenuates the Increased Plasma Levels of Thrombomodulin and von Willebrand Factor from Patients with Septic Shock
Aims: The present study assessed whether plasma levels of thrombomodulin and von Willebrand factor (vWF) are altered in patients… 
1998
1998
Polymyxin-B Stimulates Tumor Necrosis Factor-α Production by Human Peripheral Blood Mononuclear Cells
Gram-negative bacterial lipopolysaccharide (LPS) is a well known stimulus for cytokine production, particularly interleukin-1 (IL… 
1991
1991
Endotoxin filtration and immune stimulation improve survival from gram-negative sepsis.
Polymyxin B, when bound to a polystyrene fiber (PMX-F), has been used experimentally as an extracorporeal blood filter to reduce… 
1991
1991
Antagonism of endotoxic glucose dyshomeostasis by protein kinase C inhibitors.
Activation of protein kinase C (PKC) by bacterial lipopolysaccharide had recently been implicated in the pathogenetic sequence of… 
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