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PLZF-RARalpha fusion protein, human

Known as: PLZF-RARalpha, PLZF-RARalpha Fusion Protein, PLZF/RARa Protein 
A fusion protein encoded by the ZBTB16/RARA fusion gene. This protein is comprised of the N-terminal POZ domain and two of the nine zinc fingers of… Expand
National Institutes of Health

Related topics

Related topics

5 relations
Fusion GeneRARA/ZBTB16 Fusion ProteinTranscription Repressor/CorepressorZBTB16/RARA Fusion Gene

Broader (1)

Oncogene Proteins, Fusion

Papers overview

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Highly Cited
2009
Highly Cited
2009
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
The t(11;17)(q23;q21) translocation is associated with a retinoic acid (RA)-insensitive form of acute promyelocytic leukemia (APL… Expand
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Highly Cited
2004
Highly Cited
2004
Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells
ABSTRACT The acute myeloid leukemia (AML)-associated translocation products AML1-ETO, PML-retinoic acid receptor alpha (RAR… Expand
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Highly Cited
2002
Highly Cited
2002
Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways.
Signal transducer and activator of transcription (STAT) 5b-retinoic acid receptor (RAR) alpha is the fifth fusion protein… Expand
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Highly Cited
1999
Highly Cited
1999
Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha.
Acute promyelocytic leukemia (APL) is characterized by a specific chromosome translocation involving RARalpha and one of four… Expand
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Highly Cited
1998
Highly Cited
1998
IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways.
Interleukin-10 (IL-10) limits inflammatory responses by inhibiting macrophage activation. In macrophages, IL-10 activates Stat1… Expand
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Highly Cited
1998
Highly Cited
1998
Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.
Acute promyelocytic leukaemia (APL), associated with chromosomal translocations involving the retinoic acid receptor alpha gene… Expand
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Highly Cited
1998
Highly Cited
1998
Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL
Acute promyelocytic leukaemia (APL), associated with chromosomal translocations involving the retinoic acid receptor α gene (RARA… Expand
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Highly Cited
1998
Highly Cited
1998
Components of the SMRT Corepressor Complex Exhibit Distinctive Interactions with the POZ Domain Oncoproteins PLZF, PLZF-RARα, and BCL-6*
Many transcription factors function by repressing gene transcription. For a variety of these transcription factors the ability to… Expand
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Highly Cited
1998
Highly Cited
1998
Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.
Typical acute promyelocytic leukemia (APL) is associated with expression of the PML-RARalpha fusion protein and responsiveness to… Expand
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Highly Cited
1997
Highly Cited
1997
SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia.
Retinoic acid receptors (RARs) are hormone-regulated transcription factors that control key aspects of normal differentiation… Expand
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