Acute promyelocytic leukemia with a PLZF-RARalpha fusion protein.

  title={Acute promyelocytic leukemia with a PLZF-RARalpha fusion protein.},
  author={Justus H. W. Jansen and Bob L{\"o}wenberg},
  journal={Seminars in hematology},
  volume={38 1},
In most cases of acute promyelocytic leukemia (APL), a fusion of the promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha) genes occurs, resulting in the expression of a PML-RARalpha chimeric protein. In approximately 1% of the cases of APL, variant chromosomal aberrations may be found fusing RARa with other genes. Four variant mutations have been described, and the t(11;17)(q21;q23) translocation generating a promyelocyte leukemia zinc finger (PLZF)-RARalpha fusion gene… CONTINUE READING