Skip to search formSkip to main contentSkip to account menu

PLZF-RARalpha fusion protein, human

Known as: PLZF-RARalpha, PLZF-RARalpha Fusion Protein, PLZF/RARa Protein 
A fusion protein encoded by the ZBTB16/RARA fusion gene. This protein is comprised of the N-terminal POZ domain and two of the nine zinc fingers of… 
National Institutes of Health

Related topics

Related topics

5 relations
Fusion GeneRARA/ZBTB16 Fusion ProteinTranscription Repressor/CorepressorZBTB16/RARA Fusion Gene

Broader (1)

Oncogene Proteins, Fusion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
The t(11;17)(q23;q21) translocation is associated with a retinoic acid (RA)-insensitive form of acute promyelocytic leukemia (APL… 
Highly Cited
2002
Highly Cited
2002
Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways.
Signal transducer and activator of transcription (STAT) 5b-retinoic acid receptor (RAR) alpha is the fifth fusion protein… 
Highly Cited
2000
Highly Cited
2000
Two critical hits for promyelocytic leukemia.
Highly Cited
1999
Highly Cited
1999
Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha.
Acute promyelocytic leukemia (APL) is characterized by a specific chromosome translocation involving RARalpha and one of four… 
Highly Cited
1998
Highly Cited
1998
Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL
Acute promyelocytic leukaemia (APL), associated with chromosomal translocations involving the retinoic acid receptor α gene (RARA… 
Highly Cited
1998
Highly Cited
1998
Components of the SMRT Corepressor Complex Exhibit Distinctive Interactions with the POZ Domain Oncoproteins PLZF, PLZF-RARα, and BCL-6*
Many transcription factors function by repressing gene transcription. For a variety of these transcription factors the ability to… 
Highly Cited
1998
Highly Cited
1998
Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.
Acute promyelocytic leukaemia (APL), associated with chromosomal translocations involving the retinoic acid receptor alpha gene… 
Highly Cited
1998
Highly Cited
1998
Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.
Typical acute promyelocytic leukemia (APL) is associated with expression of the PML-RARalpha fusion protein and responsiveness to… 
Highly Cited
1997
Highly Cited
1997
SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia.
Retinoic acid receptors (RARs) are hormone-regulated transcription factors that control key aspects of normal differentiation… 
Highly Cited
1996
Highly Cited
1996
Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein.
Promyelocytic leukemia zinc finger-retinoic acid receptor a (PLZF-RARalpha), a fusion receptor generated as a result of a variant… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)