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PLEC protein, human

Known as: Plectin-1, plectin 1 protein, human, plectin 1, intermediate filament binding protein 500kDa, human 
Plectin (4684 aa, ~53 kDa) is encoded by the human PLEC gene. This protein plays a role in linking intermediate filaments to desmosomes or… 
National Institutes of Health

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3 relations
PLEC geneStructural gene

Broader (1)

Plectin

Papers overview

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Highly Cited
2017
Highly Cited
2017
An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin.
Organometallic metal(arene) anticancer agents require ligand exchange for their anticancer activity and this is generally… 
Highly Cited
2015
Highly Cited
2015
Plectin reinforces vascular integrity by mediating crosstalk between the vimentin and the actin networks
ABSTRACT Mutations in the cytoskeletal linker protein plectin result in multisystemic diseases affecting skin and muscle with… 
Highly Cited
2009
Highly Cited
2009
Podosome-like structures of non-invasive carcinoma cells are replaced in epithelial-mesenchymal transition by actin comet-embedded invadopodia
Podosomes and invadopodia are actin‐based structures at the ventral cell membrane, which have a role in cell adhesion, migration… 
Highly Cited
2007
Highly Cited
2007
Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin
The outer nuclear membrane proteins nesprin-1 and nesprin-2 are retained at the nuclear envelope through an interaction of their… 
Highly Cited
2007
Highly Cited
2007
Gene Expression in Temporal Lobe Epilepsy is Consistent with Increased Release of Glutamate by Astrocytes
Patients with temporal lobe epilepsy (TLE) often have a shrunken hippocampus that is known to be the location in which seizures… 
Highly Cited
2003
Highly Cited
2003
A binding motif for Siah ubiquitin ligase
The Drosophila SINA (seven in absentia) protein and its mammalian orthologs (Siah, seven in absentia homolog) are RING domain… 
Highly Cited
2003
Highly Cited
2003
Plectin-isoform-specific rescue of hemidesmosomal defects in plectin (-/-) keratinocytes.
The various plectin isoforms are among the major crosslinking elements of the cytoskeleton. The importance of plectin in… 
Highly Cited
2001
Highly Cited
2001
Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins.
MACF (microtubule actin cross-linking factor) is a large, 608-kDa protein that can associate with both actin microfilaments and… 
Highly Cited
1999
Highly Cited
1999
Immunogold EM reveals a close association of plectin and the desmin cytoskeleton in human skeletal muscle.
Highly Cited
1991
Highly Cited
1991
Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin.
Solid-phase binding assays with protein species purified from cultured rat glioma C6 cells and Ehrlich ascites revealed that… 
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