FAQ

PLEC gene

Known as: PLEC1, PLTN, Plectin Gene 
This gene plays a role in hemidesmosome structure.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1983-2017
0102019832017

Related topics

Related topics

3 relations
PLEC protein, humanPLEC wt AllelePlectin

Related mentions per year

Related mentions per year

1974-2018
197019801990200020102020
PLEC gene
PLEC protein, human
PLEC wt Allele
Plectin

Papers overview

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Highly Cited
2007
Highly Cited
2007
Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin.
The outer nuclear membrane proteins nesprin-1 and nesprin-2 are retained at the nuclear envelope through an interaction of their… (More)
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Highly Cited
2006
Highly Cited
2006
Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration
Plectin is a major intermediate filament (IF)-based cytolinker protein that stabilizes cells and tissues mechanically, regulates… (More)
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Highly Cited
2000
Highly Cited
2000
Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis.
Caspase 8 plays an essential role in the execution of death receptor-mediated apoptosis. To determine the localization of… (More)
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Highly Cited
1999
Highly Cited
1999
Genes regulating dendritic outgrowth, branching, and routing in Drosophila.
Signaling between neurons requires highly specialized subcellular structures, including dendrites and axons. Dendrites exhibit… (More)
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Highly Cited
1999
Highly Cited
1999
Binding of Integrin α6β4 to Plectin Prevents Plectin Association with F-Actin but Does Not Interfere with Intermediate Filament Binding
Hemidesmosomes are stable adhesion complexes in basal epithelial cells that provide a link between the intermediate filament… (More)
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Highly Cited
1998
Highly Cited
1998
Subunit and Plectin at Multiple Molecular Sites
Recent studies with patients suffering from epidermolysis bullosa simplex associated with muscular dystrophy and the targeted… (More)
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Highly Cited
1997
Highly Cited
1997
Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture.
Previous studies suggest that plectin, a versatile cytoskeletal linker protein, has an important role in maintaining the… (More)
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Highly Cited
1996
Highly Cited
1996
Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton
By immunogold labeling, we demonstrate that "millipede-like" structures seen previously in mammalian cell cytoskeletons after… (More)
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Highly Cited
1996
Highly Cited
1996
Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization.
Plectin is a widely expressed high molecular weight protein that is involved in cytoskeleton-membrane attachment in epithelial… (More)
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Highly Cited
1996
Highly Cited
1996
Defective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophy.
Epidermolysis bullosa simplex with muscular dystrophy (MD-EBS) is a disease characterized by generalized blistering of the skin… (More)
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