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PKN1 wt Allele

Known as: Protein Kinase N1 wt Allele, PKN-ALPHA, PRK1 
Human PKN1 wild-type allele is located in the vicinity of 19p13.12 and is approximately 39 kb in length. This allele, which encodes serine/threonine… 
National Institutes of Health

Related topics

Related topics

11 relations
19p13.12Androgen Receptor Regulation PathwayCentrosome PathwayCytoskeletal Modeling

Papers overview

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Highly Cited
2008
Highly Cited
2008
Pak1 and Pak2 Mediate Tumor Cell Invasion through Distinct Signaling Mechanisms
ABSTRACT Pak kinases are thought to play critical roles in cell migration and invasion. Here, we analyze the roles of Pak1 and… 
Highly Cited
2008
Highly Cited
2008
p21 activated kinase 5 activates Raf‐1 and targets it to mitochondria
Raf‐1 is an important effector of Ras mediated signaling and is a critical regulator of the ERK/MAPK pathway. Raf‐1 activation is… 
Highly Cited
2007
Highly Cited
2007
HIV-1 Tat Activates Dual Nox Pathways Leading to Independent Activation of ERK and JNK MAP Kinases*
Human immunodeficiency virus, type 1 Tat is known to exert pleiotropic effects on the vascular endothelium through mitogen… 
Highly Cited
2006
Highly Cited
2006
Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension.
Hypoxia is a common cause of persistent pulmonary hypertension in the newborn (PPHN), a condition associated with endothelial… 
Highly Cited
2005
Highly Cited
2005
PAK1 Negatively Regulates the Activity of the Rho Exchange Factor NET1*
Rho family small G-protein activity is controlled by guanine nucleotide exchange factors that stimulate the release of GDP, thus… 
Highly Cited
2000
Highly Cited
2000
Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton.
Growth factors such as insulin regulate phosphatidylinositol 3-kinase-dependent actin cytoskeleton rearrangement in many types of… 
Highly Cited
1998
Highly Cited
1998
PRK1 Is Targeted to Endosomes by the Small GTPase, RhoB*
RhoB has been shown to be an endosomal GTPase both by immunocytochemistry and electron microscopy, however, its role in… 
Highly Cited
1998
Highly Cited
1998
Multiple Interactions of PRK1 with RhoA
PRK1 (PKN) is a serine/threonine kinase that has been shown to be activated by RhoA (Amano, M., Mukai, H., Ono, Y., Chihara, K… 
1996
1996
The role of the unique motifs in the amino-terminal region of PKN on its enzymatic activity.
The yeast two-hybrid system and in vitro binding assay were carried out to characterize the interaction between the amino… 
Highly Cited
1994
Highly Cited
1994
Activation of PKN, a novel 120-kDa protein kinase with leucine zipper-like sequences, by unsaturated fatty acids and by limited proteolysis.
PKN, a novel protein kinase with catalytic domain homologous to PKC family and unique amino terminal leucine zipper-like… 
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