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PKI 587

Known as: PKI-587, PKI587 
National Institutes of Health

Papers overview

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2019
2019
Oxaliplatin resistance limits its effectiveness in the treatment of hepatocellular carcinoma (HCC). Abnormal activation of the… Expand
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2017
2017
Although significant improvements have been made in the treatment of acute lymphoblastic leukemia (ALL), there is a substantial… Expand
Highly Cited
2015
Highly Cited
2015
Purpose: To evaluate safety (primary endpoint), tolerability, pharmacokinetics, pharmacodynamic profile, and preliminary activity… Expand
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Highly Cited
2014
Highly Cited
2014
Although combined chemoradiotherapy has provided considerable improvements for nasopharyngeal carcinoma (NPC), recurrence and… Expand
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Highly Cited
2014
Highly Cited
2014
Background:Cetuximab is the only targeted agent approved for the treatment of head and neck squamous cell carcinomas (HNSCC), but… Expand
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2013
2013
BACKGROUND Deregulated Ras/Raf/mitogen-activated protein kinase and PI3 K/AKT/mTOR signaling pathways are significant in… Expand
Highly Cited
2012
Highly Cited
2012
BACKGROUND Deregulated Ras/Raf/MAPK and PI3K/AKT/mTOR signaling pathways are found in hepatocellular carcinoma (HCC). This study… Expand
Highly Cited
2011
Highly Cited
2011
Purpose: The aim of this study was to show preclinical efficacy and clinical development potential of PKI-587, a dual… Expand
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Highly Cited
2010
Highly Cited
2010
The PI3K/Akt signaling pathway is a key pathway in cell proliferation, growth, survival, protein synthesis, and glucose… Expand
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2010
2010
A series of mono-morpholino 1,3,5-triazine derivatives (8a-8q) bearing a 3-oxa-8-azabicyclo[3.2.1]octane were prepared and… Expand
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