PKI 587

Known as: PKI-587, PKI587 
 
National Institutes of Health

Papers overview

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2017
2017
Although significant improvements have been made in the treatment of acute lymphoblastic leukemia (ALL), there is a substantial… (More)
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2017
2017
BACKGROUND The characteristic clinical heterogeneity and mostly slow-growing behavior of gastroenteropancreatic neuroendocrine… (More)
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2015
2015
Although combined chemoradiotherapy has provided considerable improvements for nasopharyngeal carcinoma (NPC), recurrence and… (More)
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2015
2015
PURPOSE To evaluate safety (primary endpoint), tolerability, pharmacokinetics, pharmacodynamic profile, and preliminary activity… (More)
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2014
2014
Background:Cetuximab is the only targeted agent approved for the treatment of head and neck squamous cell carcinomas (HNSCC), but… (More)
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2013
2013
BACKGROUND Deregulated Ras/Raf/mitogen-activated protein kinase and PI3 K/AKT/mTOR signaling pathways are significant in… (More)
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2012
2012
BACKGROUND Deregulated Ras/Raf/MAPK and PI3K/AKT/mTOR signaling pathways are found in hepatocellular carcinoma (HCC). This study… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE The aim of this study was to show preclinical efficacy and clinical development potential of PKI-587, a dual… (More)
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2011
2011
Purpose: The aim of this study was to show preclinical efficacy and clinical development potential of PKI-587, a dual… (More)
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2010
2010
The PI3K/Akt signaling pathway is a key pathway in cell proliferation, growth, survival, protein synthesis, and glucose… (More)
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