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PKCalpha

National Institutes of Health

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protein kinase C activity

Papers overview

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2006
2006
Differential effects of melatonin and its downstream effector PKCα on subcellular localization of RGS proteins
Abstract:  Regulators of G protein signaling (RGS) are proteins that bind specifically to activated Gα subunits of heterotrimeric… 
2006
2006
PKCalpha mediates CCL18-stimulated collagen production in pulmonary fibroblasts.
A CC chemokine, CCL18, has been previously reported to stimulate collagen production in pulmonary fibroblasts. This study focused… 
2006
2006
Bile acids stimulate PKCalpha autophosphorylation and activation: role in the attenuation of prostaglandin E1-induced cAMP production in human dermal fibroblasts.
The aim was to identify the specific PKC isoform(s) and their mechanism of activation responsible for the modulation of cAMP… 
2005
2005
The PKCalpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals.
Protein kinase C (PKC) is a key regulator of cell proliferation, differentiation, and apoptosis and is one of the drug targets of… 
2005
2005
1-Butanol interferes with phospholipase D1 and protein kinase Calpha association and inhibits phospholipase D1 basal activity.
2004
2004
Protein Kinase Cα Translocates to the Perinuclear Region to Activate Phospholipase D1*
The inhibition of phorbol ester activation of phospholipase D1 (PLD1) by protein kinase C (PKC) inhibitors has been considered… 
2003
2003
Inhibition of PKCalpha induces a PKCdelta-dependent apoptotic program in salivary epithelial cells.
We have used expression of a kinase dead mutant of PKCalpha (PKCalphaKD) to explore the role of this isoform in salivary… 
2002
2002
Identification of PKCalpha isoform-specific effects in cardiac myocytes using antisense phosphorothioate oligonucleotides.
Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in multiple cellular processes. In the… 
1999
1999
Downregulation of Protein Kinase Cδ Activity Enhances Endothelial Cell Adaptation to Hypoxia
Background—Although protein kinase C (PKC) has been implicated in ischemic cell death, the role of individual PKC isoenzymes in… 
Highly Cited
1997
Highly Cited
1997
Activation of PKCα Downstream from Caspases during Apoptosis Induced by 7-Hydroxystaurosporine or the Topoisomerase Inhibitors, Camptothecin and Etoposide, in Human Myeloid Leukemia HL60 Cells*
We previously demonstrated that the anticancer agent and protein kinase C (PKC) inhibitor 7-hydroxystaurosporine (UCN-01) induces… 
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