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Many of the sodium‐dependent neurotransmitter transporters are rapidly (within minutes) regulated by protein kinase C (PKC), with… Expand Heterotrimeric G-proteins of the Gα12/13 family activate Rho GTPase through the guanine nucleotide exchange factor p115RhoGEF… Expand Sodium-dependent transporters clear extracellular glutamate in the mammalian CNS. Activation of protein kinase C (PKC) rapidly… Expand Phorbol esters, the archetypical (PKC) activators, induce apoptosis in androgen-sensitive LNCaP prostate cancer cells. In this… Expand Although protein kinase C (PKC) activation is required for endothelial cell (EC) growth, migration, adhesion, and vessel… Expand Hypoxia induces endothelial dysfunction that results in a series of cardiovascular injuries. Early growth response‐1 (Egr‐1) has… Expand Receptor-coupled contraction of smooth muscle involves recruitment to the plasma membrane of downstream effector molecules… Expand Protein kinase C (PKC) has been implicated in integrin-mediated spreading and migration. In mammary epithelial cells there is a… Expand We previously demonstrated that the anticancer agent and protein kinase C (PKC) inhibitor 7-hydroxystaurosporine (UCN-01) induces… Expand Ceramide mediates the effects of extracellular agents on cellular growth, differentiation and apoptosis. In this study, we… Expand