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PKCalpha

National Institutes of Health

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protein kinase C activity

Papers overview

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2006
2006
Differential effects of melatonin and its downstream effector PKCα on subcellular localization of RGS proteins
Abstract:  Regulators of G protein signaling (RGS) are proteins that bind specifically to activated Gα subunits of heterotrimeric… 
2006
2006
CXCR2 ligands and G-CSF mediate PKCalpha-induced intraepidermal inflammation.
Transgenic mice overexpressing PKCalpha in the epidermis (K5-PKCalpha mice) exhibit an inducible severe intraepidermal… 
Highly Cited
2005
Highly Cited
2005
Evidence that protein kinase Cα interacts with and regulates the glial glutamate transporter GLT‐1
Many of the sodium‐dependent neurotransmitter transporters are rapidly (within minutes) regulated by protein kinase C (PKC), with… 
2005
2005
The PKCalpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals.
Protein kinase C (PKC) is a key regulator of cell proliferation, differentiation, and apoptosis and is one of the drug targets of… 
2004
2004
Protein Kinase Cα Translocates to the Perinuclear Region to Activate Phospholipase D1*
The inhibition of phorbol ester activation of phospholipase D1 (PLD1) by protein kinase C (PKC) inhibitors has been considered… 
2004
2004
The Luteinizing Hormone-releasing Hormone Inhibits the Anti-apoptotic Activity of Insulin-like Growth Factor-1 in Pituitary αT3 Cells by Protein Kinase Cα-mediated Negative Regulation of Akt*
The luteinizing hormone-releasing hormone (LHRH) receptor is a G protein-coupled receptor involved in the synthesis and release… 
Highly Cited
2003
Highly Cited
2003
Phorbol Myristate Acetate-Dependent Interaction of Protein Kinase Cα and the Neuronal Glutamate Transporter EAAC1
Sodium-dependent transporters clear extracellular glutamate in the mammalian CNS. Activation of protein kinase C (PKC) rapidly… 
2000
2000
Effect of receptor-selective retinoids on growth and differentiation pathways in mouse melanoma cells.
1999
1999
Downregulation of Protein Kinase Cδ Activity Enhances Endothelial Cell Adaptation to Hypoxia
Background—Although protein kinase C (PKC) has been implicated in ischemic cell death, the role of individual PKC isoenzymes in… 
Highly Cited
1997
Highly Cited
1997
Activation of PKCα Downstream from Caspases during Apoptosis Induced by 7-Hydroxystaurosporine or the Topoisomerase Inhibitors, Camptothecin and Etoposide, in Human Myeloid Leukemia HL60 Cells*
We previously demonstrated that the anticancer agent and protein kinase C (PKC) inhibitor 7-hydroxystaurosporine (UCN-01) induces… 
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