PIAS1 gene

Known as: PIAS1, GU-BINDING PROTEIN, protein inhibitor of activated STAT 1 
This gene is involved in both signal transduction and the sumoylation of proteins.
National Institutes of Health

Papers overview

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2012
2012
The ubiquitin-like SUMO proteins covalently modify protein substrates and regulate their functional properties. In a broad… (More)
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2010
2010
CD4(+)Foxp3(+) regulatory T (T(reg)) cells are important for maintaining immune tolerance. Understanding the molecular mechanism… (More)
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Highly Cited
2009
Highly Cited
2009
Here, we show that the major mosquito vector for dengue virus uses the JAK-STAT pathway to control virus infection. Dengue virus… (More)
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Highly Cited
2008
Highly Cited
2008
Blood 1986; 68: 1369–1375. 3 Van Limbergen H, Beverloo HB, van Drunen E, Janssens A, Hahlen K, Poppe B et al. Molecular… (More)
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Highly Cited
2007
Highly Cited
2007
Posttranslational modifications of proteins by small ubiquitin-like modifiers (SUMOs) regulate protein degradation and… (More)
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Highly Cited
2004
Highly Cited
2004
Interferon (IFN) activates the signal transducer and activator of transcription (STAT) pathway to regulate immune responses. The… (More)
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Review
2002
Review
2002
IL-6 is a pleiotropic cytokine with a wide range of biological activities in immune regulation, hematopoiesis, inflammation, and… (More)
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Highly Cited
2002
Highly Cited
2002
The androgen receptor (AR) has been shown to be modified by SUMO-1, a ubiquitin-like protein. Recently we showed that PIAS family… (More)
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Highly Cited
2000
Highly Cited
2000
Gabapentin (GBP; Neurontin) has proven efficacy in several neurological and psychiatric disorders yet its mechanism of action… (More)
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Highly Cited
1998
Highly Cited
1998
STAT (signal transducer and activator of transcription) proteins are latent cytoplasmic transcription factors that become… (More)
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