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PFKFB4 gene

Known as: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 4, PFKFB4 
National Institutes of Health

Related topics

Related topics

1 relation
6-Phosphofructo-2-kinase

Papers overview

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2018
2018
Synthesis and mechanistic studies of quinolin-chlorobenzothioate derivatives with proteasome inhibitory activity in pancreatic cancer cell lines.
2018
2018
Analysis of Malignant Melanoma Cell Lines Exposed to Hypoxia Reveals the Importance of PFKFB4 Overexpression for Disease Progression
Background/Aim: Most melanomas develop in hypoxic conditions. Since hypoxia via HIF-1 induces glycolysis, a process essential for… 
Review
2017
Review
2017
PFKFB 4 control of Akt signaling is essential for premigratory and 1 migratory neural crest formation . 2 3
28 Neural crest (NC) specification comprises an early phase, initiating immature NC progenitors 29 formation at neural plate… 
2016
2016
Targeting PFKFB4 in mitotically vulnerable ovarian cancer cells
Taxanes represent some of the most common chemotherapeutic agents for ovarian cancer treatment. However, they are only effective… 
2015
2015
Targeting 6‐Phosphofructo‐2‐kinase/Fructose‐2,6‐Bisphosphatase‐4 (PFKFB4) in Cancer
High glycolytic flux, even in the presence of oxygen (i.e. the Warburg effect), is a central neoplastic hallmark. Oncogenic… 
2015
2015
Control of cell specification and migration during early frog development by PFKFB4, a key glycolysis regulator
L’ectoderme embryonnaire devient specifie en ectoderme non-neural, plaque neurale et bordure neurale a la fin de la gastrulation… 
2013
2013
Expression of Genes Encoded 6-phosphofructo-2-kinase/fructose-2, 6- bisphosphatase and 6-phosphofructo-1-kinase in U87 Glioma Cells with ERN1 Loss of Function: Hypoxic Regulation
The endoplasmic reticulum–nuclei-1 (ERN1) sensing and signaling enzyme mediates a set of complex intracellular signaling events… 
2012
2012
220 PFKFB4 is Essential for Prostate Cancer Cell Survival by Maintaining the Balance Between the Use of Glucose for Energy Generation and the Synthesis of Anti-oxidants
2007
2007
Requirement of PFKFB4 in anchorage independent growth and tumorigenesis
A88 Transformed cells need abundant glucose relative to normal cells in order to satisfy their increased anabolic and energetic… 
2005
2005
in Human Cancer 2 , 6-Bisphosphatase / PFKFB 3 Family of Glycolytic Regulators Phosphorylation of the 6-Phosphofructo-2-Kinase / Fructose Updated
Purpose: Fructose 2,6-bisphosphate (F2,6BP) is a potent activator of phosphofructokinase, which is a rate-limiting enzyme of… 
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