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PF-670462

 
National Institutes of Health

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1 relation

Broader (1)

Pyrimidines

Papers overview

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2013
2013
Modeling and Validating Chronic Pharmacological Manipulation of Circadian Rhythms
Circadian rhythms can be entrained by a light-dark (LD) cycle and can also be reset pharmacologically, for example, by the CK1… Expand
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2013
2013
Casein Kinase 1δ Activity: A Key Element in the Zebrafish Circadian Timing System
Zebrafish have become a popular model for studies of the circadian timing mechanism. Taking advantage of its rapid development of… Expand
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2012
2012
Inhibition of the Casein-Kinase-1-Epsilon/Delta Prevents Relapse-Like Alcohol Drinking
During the past decade, it has been shown that circadian clock genes have more than a simple circadian time-keeping role. Clock… Expand
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2011
2011
Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation.
The closely related δ and ε isoforms of the serine/threonine protein kinase casein kinase 1 (Csnk1) have been implicated in the… Expand
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Highly Cited
2010
Highly Cited
2010
Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.
Circadian pacemaking requires the orderly synthesis, posttranslational modification, and degradation of clock proteins. In… Expand
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Highly Cited
2009
Highly Cited
2009
Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.
The circadian clock links our daily cycles of sleep and activity to the external environment. Deregulation of the clock is… Expand
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2009
2009
Selective Inhibition of Casein Kinase 1 Minimally Alters Circadian Clock Period
The circadian clock links our daily cycles of sleep and activity to the external environment. Deregulation of the clock is… Expand
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2009
2009
Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys
IntroductionCircadian rhythms in mammals depend upon the cyclic oscillations of transcriptional/translational feedback loops in… Expand
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2008
2008
A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine
RationaleWe previously colocalized a quantitative trait locus (QTL) for sensitivity to the locomotor stimulant effects of… Expand
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Highly Cited
2007
Highly Cited
2007
An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions.
Casein kinase Iepsilon (CKIepsilon) is an essential component of the biological clock, phosphorylating PER proteins, and in doing… Expand
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