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PF-670462

 

Topic mentions per year

Topic mentions per year

2007-2018
012320072018

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Related topics

1 relation

Broader (1)

Pyrimidines

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
PF-670462
Pyrimidines

Papers overview

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2012
2012
Inhibition of the Casein-Kinase-1-Epsilon/Delta Prevents Relapse-Like Alcohol Drinking
During the past decade, it has been shown that circadian clock genes have more than a simple circadian time-keeping role. Clock… (More)
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2012
2012
An inhibitor of casein kinase 1 ε/δ partially normalizes the manic-like behaviors of the ClockΔ19 mouse.
Bipolar disorder is a terrible and debilitating disease with limited treatment options. Circadian rhythm disruptions are… (More)
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2011
2011
Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation.
The closely related δ and ε isoforms of the serine/threonine protein kinase casein kinase 1 (Csnk1) have been implicated in the… (More)
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2011
2011
Rapid, Computer Vision-Enabled Murine Screening System Identifies Neuropharmacological Potential of Two New Mechanisms
The lack of predictive in vitro models for behavioral phenotypes impedes rapid advancement in neuropharmacology and… (More)
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Highly Cited
2010
Highly Cited
2010
Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.
Circadian pacemaking requires the orderly synthesis, posttranslational modification, and degradation of clock proteins. In… (More)
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2010
2010
Chronic treatment with a selective inhibitor of casein kinase I δ/ε yields cumulative phase delays in circadian rhythms
Casein kinase I ε/δ phosphorylates certain clock-related proteins as part of a complex arrangement of transcriptional… (More)
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2009
2009
Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.
The circadian clock links our daily cycles of sleep and activity to the external environment. Deregulation of the clock is… (More)
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2009
2009
Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys
Circadian rhythms in mammals depend upon the cyclic oscillations of transcriptional/translational feedback loops in pacemaker… (More)
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2008
2008
A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine
We previously colocalized a quantitative trait locus (QTL) for sensitivity to the locomotor stimulant effects of methamphetamine… (More)
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Highly Cited
2007
Highly Cited
2007
An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions.
Casein kinase Iepsilon (CKIepsilon) is an essential component of the biological clock, phosphorylating PER proteins, and in doing… (More)
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