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PF-670462

National Institutes of Health

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Pyrimidines

Papers overview

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2012
2012
An inhibitor of casein kinase 1 &egr;/&dgr; partially normalizes the manic-like behaviors of the Clock&Dgr;19 mouse
Bipolar disorder is a terrible and debilitating disease with limited treatment options. Circadian rhythm disruptions are… 
2011
2011
Casein kinase 1 enables nucleus accumbens amphetamine‐induced locomotion by regulating AMPA receptor phosphorylation
J. Neurochem. (2011) 118, 237–247. 
2011
2011
Casein kinase 1 (Csnk1) is a serine/threonine protein kinase that phosphorylates a wide array of substrates, is involved in the regulation of diverse cellular processes, and is richly expressed in…
The closely related d and e isoforms of the serine/threonine protein kinase casein kinase 1 (Csnk1) have been implicated in the… 
2010
2010
Chronic treatment with a selective inhibitor of casein kinase I δ/ε yields cumulative phase delays in circadian rhythms
IntroductionCasein kinase I ε/δ phosphorylates certain clock-related proteins as part of a complex arrangement of transcriptional… 
2009
2009
Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys
IntroductionCircadian rhythms in mammals depend upon the cyclic oscillations of transcriptional/translational feedback loops in… 
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