PF-670462
National Institutes of Health
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Casein kinase 1δ/ε (CK1δ/ε) is a key component of noncanonical Wnt signaling pathways, which were shown previously to drive…
Circadian rhythms can be entrained by a light‐dark (LD) cycle and can also be reset pharmacologically, for example, by the CK1…
Zebrafish have become a popular model for studies of the circadian timing mechanism. Taking advantage of its rapid development of…
During the past decade, it has been shown that circadian clock genes have more than a simple circadian time-keeping role. Clock…
Bipolar disorder is a terrible and debilitating disease with limited treatment options. Circadian rhythm disruptions are…
J. Neurochem. (2011) 118, 237–247.
Circadian pacemaking requires the orderly synthesis, posttranslational modification, and degradation of clock proteins. In…
IntroductionCasein kinase I ε/δ phosphorylates certain clock-related proteins as part of a complex arrangement of transcriptional…
The circadian clock links our daily cycles of sleep and activity to the external environment. Deregulation of the clock is…
Casein kinase Iepsilon (CKIepsilon) is an essential component of the biological clock, phosphorylating PER proteins, and in doing…