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PF-670462

 
National Institutes of Health

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1 relation

Broader (1)

Pyrimidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Modeling and Validating Chronic Pharmacological Manipulation of Circadian Rhythms
Circadian rhythms can be entrained by a light‐dark (LD) cycle and can also be reset pharmacologically, for example, by the CK1… Expand
2013
2013
Casein Kinase 1δ Activity: A Key Element in the Zebrafish Circadian Timing System
Zebrafish have become a popular model for studies of the circadian timing mechanism. Taking advantage of its rapid development of… Expand
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2012
2012
Inhibition of the Casein-Kinase-1-Epsilon/Delta Prevents Relapse-Like Alcohol Drinking
During the past decade, it has been shown that circadian clock genes have more than a simple circadian time-keeping role. Clock… Expand
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2012
2012
An inhibitor of casein kinase 1 &egr;/&dgr; partially normalizes the manic-like behaviors of the Clock&Dgr;19 mouse
Bipolar disorder is a terrible and debilitating disease with limited treatment options. Circadian rhythm disruptions are… Expand
2011
2011
Casein kinase 1 enables nucleus accumbens amphetamine‐induced locomotion by regulating AMPA receptor phosphorylation
J. Neurochem. (2011) 118, 237–247. 
Highly Cited
2010
Highly Cited
2010
Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes
Circadian pacemaking requires the orderly synthesis, posttranslational modification, and degradation of clock proteins. In… Expand
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2010
2010
Chronic treatment with a selective inhibitor of casein kinase I δ/ε yields cumulative phase delays in circadian rhythms
IntroductionCasein kinase I ε/δ phosphorylates certain clock-related proteins as part of a complex arrangement of transcriptional… Expand
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Highly Cited
2009
Highly Cited
2009
Selective Inhibition of Casein Kinase 1ϵ Minimally Alters Circadian Clock Period
The circadian clock links our daily cycles of sleep and activity to the external environment. Deregulation of the clock is… Expand
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2009
2009
Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys
IntroductionCircadian rhythms in mammals depend upon the cyclic oscillations of transcriptional/translational feedback loops in… Expand
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Highly Cited
2007
Highly Cited
2007
An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions.
Casein kinase Iepsilon (CKIepsilon) is an essential component of the biological clock, phosphorylating PER proteins, and in doing… Expand
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