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PF-562,271

 
National Institutes of Health

Papers overview

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2017
2017
Focal adhesion kinase (FAK) is considered as an attractive target for oncology. A series of F-18 labeled 5-bromo-N2-(4-(2-fluoro… Expand
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2015
2015
Glioblastoma is one of the most aggressive and fatal brain cancers due to the highly invasive nature of glioma cells. Microglia… Expand
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2014
2014
Ovarian clear cell carcinoma (OCCC) displays a higher resistance to first line chemotherapy, requiring the development of new… Expand
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2013
2013
The focal adhesion kinase inhibitor, PF-562,271, is currently in clinical development for cancer, however it is not known how PF… Expand
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2012
2012
Focal adhesion kinase (FAK) is upregulated in several epithelial tumours and there has been considerable interest in developing… Expand
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Highly Cited
2011
Highly Cited
2011
Current therapies for pancreatic ductal adenocarcinoma (PDA) target individual tumor cells. Focal adhesion kinase (FAK) is… Expand
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2010
2010
Focal adhesion kinase (FAK) is essential in regulating integrin signaling pathways responsible for cell survival and… Expand
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2009
2009
EXPERIMENTAL DESIGN To investigate the antitumor effect of sunitinib and FAK/Pyk2 tyrosine kinase inhibitor (PF-562,271… Expand
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Highly Cited
2008
Highly Cited
2008
Cancer cells are characterized by the ability to grow in an anchorage-independent manner. The activity of the nonreceptor… Expand
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2008
2008
BACKGROUND Lytic bone metastases occur frequently in cancer patients and present major clinical issues including lack of… Expand
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