Skip to search formSkip to main contentSkip to account menu

PF-477736

Known as: PF-00477736, PF477736 
National Institutes of Health

Related topics

Related topics

2 relations
CHK1 Inhibitor PF-477736PF 00477736

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Chk-mate on resistance to kinase inhibitors
The invariable development of drug resistance represents a major obstacle to the successful treatment of cancer with kinase… 
2017
2017
Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition
Reduction in nucleotide pools through the inhibition of mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) has been… 
2015
2015
Synergism between bosutinib (SKI-606) and the Chk1 inhibitor (PF-00477736) in highly imatinib-resistant BCR/ABL⁺ leukemia cells.
2014
2014
Chk 1 Inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers
Background: Chk1 inhibitors are currently in clinical trials as putative potentiators of cytotoxic chemotherapy drugs. Chk1… 
2014
2014
Abstract 1600: Keeping glioblastoma (GBM)in check by targeting the CHK1-STAT3-CIP2A axis
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Checkpoint kinase1 (CHK1) is a DNA damage kinase, which… 
2014
2014
Abstract 2766: Inhibition of Chk1 and Wee1 as a new therapeutic approach in Mantle Cell Lymphoma
Mantle Cell Lymphoma (MCL) is an aggressive lymphoma, for which there is not yet a standard therapy. Deregulation of cell cycle… 
2013
2013
Investigating the predictors of sensitivity to the Chk1 inhibitor PF-00477736 in melanoma
2011
2011
Abstract 2549: Efficacy of the Chk1 inhibitor PF-00477736 and pemetrexed in human mesothelioma
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Malignant pleural mesothelioma (MPM) is a highly… 
Highly Cited
2009
Highly Cited
2009
PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts
Purpose: Checkpoint kinase 1 (Chk1) plays a critical role in the activation of mitotic spindle checkpoint and DNA damage… 
2007
2007
Mechanisms of radiation enhancement by the CHK1 inhibitor PF-477736
5386 CHK1 kinase is a key regulator of the S and G2 cell cycle checkpoints that are activated in response to DNA damage. Cell… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)