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PF-477736

Known as: PF-00477736, PF477736 
 
National Institutes of Health

Papers overview

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2015
2015
Mantle cell lymphoma (MCL) is an aggressive, incurable disease, characterized by a deregulated cell cycle. Chk1 and Wee1 are main… Expand
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2015
2015
BackgroundAlthough progress in children, in adults, ALL still carries a dismal outcome. Here, we explored the in vitro and in… Expand
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2015
2015
Interactions between the dual BCR/ABL and Src inhibitor bosutinib and the Chk1 inhibitor PF-00477736 were examined in BCR/ABL… Expand
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2014
2014
Oral squamous cell carcinoma (OSCC), a subset of head and neck squamous cell carcinoma (HNSCC), is the eighth most common cancer… Expand
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2013
2013
PURPOSE Despite the comparably high cure rates observed for HPV-positive HNSCC, there is still a great need for specific tumor… Expand
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Highly Cited
2012
Highly Cited
2012
Targeting Chk1 protein kinase can enhance the antitumor effects of radio- and chemotherapy. Recent evidence disclosed a role of… Expand
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2010
2010
Checkpoint kinase 1 (Chk1), a member of the serine/threonine kinase family, is an attractive therapeutic target for anticancer… Expand
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2010
2010
3062 Background: The S-phase and G2-checkpoints are critical mediators of the cell cycle response to cytotoxic therapy. PF-736 is… Expand
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2009
2009
PURPOSE Checkpoint kinase 1 (Chk1) plays a critical role in the activation of mitotic spindle checkpoint and DNA damage… Expand
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Highly Cited
2008
Highly Cited
2008
Checkpoints are present in all phases of the cell cycle and are regarded as the gatekeepers maintaining the integrity of the… Expand
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