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Mantle cell lymphoma (MCL) is an aggressive, incurable disease, characterized by a deregulated cell cycle. Chk1 and Wee1 are main… Expand BackgroundTopotecan (TPT) is a therapeutic option for women with platinum-resistant or -refractory ovarian cancer. However, the… Expand BackgroundAlthough progress in children, in adults, ALL still carries a dismal outcome. Here, we explored the in vitro and in… Expand Background: UV wavelengths of sunlight exacerbate the symptoms of autoimmunity. Results: UV and UV-mimetic chemical carcinogens… Expand Oral squamous cell carcinoma (OSCC), a subset of head and neck squamous cell carcinoma (HNSCC), is the eighth most common cancer… Expand PURPOSE
Despite the comparably high cure rates observed for HPV-positive HNSCC, there is still a great need for specific tumor… Expand Targeting Chk1 protein kinase can enhance the antitumor effects of radio- and chemotherapy. Recent evidence disclosed a role of… Expand 3062 Background: The S-phase and G2-checkpoints are critical mediators of the cell cycle response to cytotoxic therapy. PF-736 is… Expand Purpose: Checkpoint kinase 1 (Chk1) plays a critical role in the activation of mitotic spindle checkpoint and DNA damage… Expand Checkpoints are present in all phases of the cell cycle and are regarded as the gatekeepers maintaining the integrity of the… Expand