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CHK1 Inhibitor PF-477736
A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity. Chk1 inhibitor PF-477736 inhibits…
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National Institutes of Health
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PF 00477736
PF-477736
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Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Cancer Therapy : Preclinical Gemcitabine and CHK 1 Inhibition Potentiate EGFR-Directed Radioimmunotherapy against Pancreatic Ductal Adenocarcinoma
F. Al-Ejeh
,
M. Pajic
,
+8 authors
K. Khanna
2014
Corpus ID: 2826352
Purpose: To develop effective combination therapy against pancreatic ductal adenocarcinoma (PDAC) with a combination of…
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2006
2006
Imaging with FLT-PET demonstrates that PF-477736, an inhibitor of CHK1 kinase, overcomes a cell cycle checkpoint induced by gemcitabine in PC-3 xenografts.
G. McArthur
,
J. Raleigh
,
+8 authors
K. Anderes
Journal of Clinical Oncology
2006
Corpus ID: 20660422
3045 Background: The development of strategies to monitor the molecular and cellular response to novel agents that target the…
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