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PF-429242

National Institutes of Health

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Broader (1)

Pyrrolidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma.
Enhancer of zeste homolog 2 (EZH2) mediates epigenetic gene silencing via tri-methylation of histone H3 lysine 27 (H3K27-me3… 
2018
2018
Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death
2018
2018
The cholesterol, fatty acid and triglyceride synthesis pathways regulated by site 1 protease (S1P) are required for efficient replication of severe fever with thrombocytopenia syndrome virus.
2017
2017
Site-1 protease, a novel metabolic target for glioblastoma.
Highly Cited
2017
Highly Cited
2017
Antiviral Activity of Nordihydroguaiaretic Acid and Its Derivative Tetra-O-Methyl Nordihydroguaiaretic Acid against West Nile Virus and Zika Virus
ABSTRACT Flaviviruses are positive-strand RNA viruses distributed all over the world that infect millions of people every year… 
2016
2016
Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation
Dengue virus (DENV) infection causes one of the most widespread mosquito-borne diseases in the world. Despite the great need… 
2015
2015
SKI-1/S1P inhibitor PF-429242 impairs the onset of HCV infection.
Highly Cited
2012
Highly Cited
2012
Human Subtilase SKI-1/S1P Is a Master Regulator of the HCV Lifecycle and a Potential Host Cell Target for Developing Indirect-Acting Antiviral Agents
HCV infection is a major risk factor for liver cancer and liver transplantation worldwide. Overstimulation of host lipid… 
Highly Cited
2010
Highly Cited
2010
Antiviral Activity of a Small-Molecule Inhibitor of Arenavirus Glycoprotein Processing by the Cellular Site 1 Protease
ABSTRACT Arenaviruses merit interest as clinically important human pathogens and include several causative agents, chiefly Lassa… 
Highly Cited
2008
Highly Cited
2008
Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells…
Sterol regulatory element-binding proteins (SREBPs) are major transcriptional regulators of cholesterol, fatty acid, and glucose… 
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