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PF 3758309

Known as: PF-3758309, PF3758309 
National Institutes of Health

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2 relations

Broader (2)

PyrazolesPyrroles

Papers overview

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2018
2018
The PAK Inhibitor PF-3758309 Promotes the Inhibitory Effects of Multiple Chemotherapeutic Reagents on Patient-Derived Pancreatic Cancer Cell Lines
Pancreatic ductal adenocarcinoma (PDA) remains the most lethal malignancy due to lack of an effective treatment. P21-activated… 
2017
2017
Multiple myeloma cells sent "PAKing"!
In this issue of Blood, Fulciniti et al report on the role of p21-activated kinase 4 (PAK4), a member of the p21-activated… 
2011
2011
Contribution of the epithelial-mesenchymal (EMT) phenotype to the sensitivity of colorectal cancer cell lines to the p21-activated kinase inhibitor, PF-3758309.
438 Background: Increased expression of p21-activated kinase (PAK) family proteins has been observed in a range of malignancies… 
2009
2009
Abstract #DDT01-3: Identification of the p21-activated kinase inhibitor PF-3758309: A key effector of Ras signaling
The p21-activated kinase (PAK) family members are key effectors of Rho family GTPases. These small G protein act as regulatory… 
2006
2006
Evolutionarily Conserved Wnk and Ste20 Kinases Are Essential for Acute Volume Recovery and Survival after Kinase to Regulate P21waf1/cip1 Stability Mst Kinases Monitor Actin Cytoskeletal Integrity…
[PDF] [Full Text] [Abstract] , September 1, 2007; 293 (3): C915-C927. Am J Physiol Cell Physiol K. P. Choe and K. Strange… 
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