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PF-05082566
Known as:
4-1BB Agonist Monoclonal Antibody PF-05082566
, PF-2566
A fully human, agonistic immunoglobulin (Ig) G2 monoclonal antibody (mAb) targeting 4-1BB (CD137, TNFRSF9), with potential immunostimulating activity…
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National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Immunoglobulin G
Monoclonal Antibodies
antigen binding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
S. Chin
,
C. Kimberlin
,
+13 authors
J. Chaparro-Riggers
Nature Communications
2018
Corpus ID: 256641245
4-1BB (CD137, TNFRSF9) is an inducible costimulatory receptor expressed on activated T cells. Clinical trials of two agonist…
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Highly Cited
2017
Highly Cited
2017
Phase Ib Study of Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Combination with Pembrolizumab (MK-3475) in Patients with Advanced Solid Tumors
A. Tolcher
,
M. Sznol
,
+11 authors
L. Chow
Clinical Cancer Research
2017
Corpus ID: 3402309
Purpose: This phase Ib study (NCT02179918) evaluated the safety, antitumor activity, pharmacokinetics, and pharmacodynamics of…
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2017
2017
A PHASE I STUDY OF UTOMILUMAB (PF‐05082566), A 4‐1BB/CD137 AGONIST, IN COMBINATION WITH RITUXIMAB IN PATIENTS WITH CD20+ NON‐HODGKIN'S LYMPHOMA
A. Gopal
,
R. Levy
,
+10 authors
N. Bartlett
2017
Corpus ID: 79478808
A PHASE I STUDY OF UTOMILUMAB (PF‐ 05082566), A 4‐1BB/CD137 AGONIST, IN COMBINATION WITH RITUXIMAB IN PATIENTS WITH CD20 NON…
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2016
2016
Phase Ib study of PF-05082566 in combination with pembrolizumab in patients with advanced solid tumors.
A. Tolcher
,
M. Sznol
,
+11 authors
L. Chow
2016
Corpus ID: 77924516
3002Background: PF-05082566 (PF-2566) is a fully human IgG2 monoclonal antibody (mAb) that binds to human 4-1BB (CD137…
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2015
2015
A phase I study of PF-05082566 (anti-4-1BB) + rituximab in patients with CD20+ NHL.
A. Gopal
,
N. Bartlett
,
+8 authors
H. Kohrt
2015
Corpus ID: 79449422
3004 Background: 4-1BB agonists enhance cytotoxic T-cell and NK cell responses, including antibody-dependent cellular…
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2015
2015
Functional expression of CD137 (4-1BB) on T helper follicular cells
C. Alfaro
,
J. Echeveste
,
+11 authors
I. Melero
Oncoimmunology
2015
Corpus ID: 31781484
CD137 (4-1BB) is a surface protein initially discovered to mark activated T lymphocytes. However, its broader expression pattern…
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Highly Cited
2012
Highly Cited
2012
Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity
T. Fisher
,
Cris Kamperschroer
,
+10 authors
L. Sharp
Cancer Immunology and Immunotherapy
2012
Corpus ID: 5687057
Abstract4-1BB (CD137, TNFRSF9) is a costimulatory receptor expressed on several subsets of activated immune cells. Numerous…
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2012
2012
Abstract 4384: Targeting of 4-1BB by monoclonal antibody, PF-05082566, enhances T cell function and promotes antitumor activity
T. Fisher
,
Cris Kamperschroer
,
+10 authors
L. Sharp
2012
Corpus ID: 71429059
4-1BB (CD137, TNFRSF9) is a costimulatory receptor expressed in an activation induced manner on several subsets of immune cells…
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