PF-04691502

Known as: PI3K/mTOR Kinase Inhibitor PF-04691502 
An agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with… (More)

Topic mentions per year

Topic mentions per year

2011-2017
051020112017

Papers overview

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2016
2016
OBJECTIVE PF-04691502 and gedatolisib (PF-05212384) are potent, dual PI3K/mTOR inhibitors. This phase II study (B1271004) was… (More)
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2016
2016
Lung cancer is the leading cause of cancer deaths in both men and women in the United States accounting for about 27% of all… (More)
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2015
2015
Current treatment strategies for chronic lymphocytic leukemia (CLL) involve a combination of conventional chemotherapeutics… (More)
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2013
2013
PURPOSE Phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway activation is often associated with altered… (More)
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2013
2013
PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide) mutations can help predict the antitumor activity of… (More)
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2013
2013
Hepatocellular carcinoma (HCC) is a major cause of morbidity and mortality in the world. The aim of the present study is to… (More)
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2013
2013
Nasopharyngeal carcinoma (NPC) is common in Southeast Asia and over 40 % of NPC tissues have PIK3CA amplification. This study… (More)
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2013
2013
Purpose To determine the maximum tolerated dose (MTD), safety, pharmacokinetics, pharmacodynamics, and preliminary evidence of… (More)
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Highly Cited
2011
Highly Cited
2011
Deregulation of the phosphoinositide 3-kinase (PI3K) signaling pathway such as by PTEN loss or PIK3CA mutation occurs frequently… (More)
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2011
2011
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is commonly dysregulated in human cancer, making it an attractive target for… (More)
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