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Incidence trends of mantle cell lymphoma in the United States between 1992 and 2004
The purpose of the current study was to examine the incidence of MCL over a period of 13 years and to identify the factors associated with the incidence patterns.
miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect.
It is demonstrated that miRNAs (miR-124, miR-137 and miR -340) impair colorectal cancer by counteracting the Warburg effect due to regulating alternative splicing of the PKM gene.
A novel germline mutation in SDHA identified in a rare case of gastrointestinal stromal tumor complicated with renal cell carcinoma.
- Quan Jiang, Yong Zhang, +6 authors W. Lu
- Biology, MedicineInternational journal of clinical and…
- 1 October 2015
A rare case diagnosed as a WT GIST complicated with a synchronous renal chromophobe cell tumor and detected a novel germline heterozygous mutation (c.2T>C: p.M1T) in the initiation codon of the SDHA gene is presented.
High incidence of severe neutropenia after gemcitabine-based chemotherapy in Chinese cancer patients with CDA 79A>C mutation.
- Jialin Xu, Yuhong Zhou, +4 authors Weimin Cai
- MedicineClinica chimica acta; international journal of…
- 16 August 2012
The study suggests that CDA 79A>C mutation might be a potential risk factor of gemcitabine-induced neutropenia toxicity and allele-specific PCR and restriction fragment length polymorphism are suggested.
Primary Tumour Resection Could Improve the Survival of Unresectable Metastatic Colorectal Cancer Patients Receiving Bevacizumab-Containing Chemotherapy
- Zhi-ming Wang, L. Liang, +6 authors Tianshu Liu
- MedicineCellular Physiology and Biochemistry
- 1 September 2016
The mCRC patients who received PTR and bevacizumab combination chemotherapy had better clinical outcomes than patients who did not receive PTR, and PTR decreased the incidence of severe clinical events and improved quality of life.
SREBP1 regulates tumorigenesis and prognosis of pancreatic cancer through targeting lipid metabolism
The results indicate that SREBP1 had important role in tumor progression and appears to be a novel prognostic marker for pancreatic cancer.
Electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy in multiple myeloma: a feasibility study
- M. K. Garcia, L. Cohen, +17 authors Michael L. Wang
- MedicineJournal of Hematology & Oncology
- 9 May 2014
Acupuncture may help patients experiencing thalidomide- or bortezomib-induced peripheral neuropathy in cancer patients with multiple myeloma, and larger, randomized, clinical trials are needed.
The Pro-Apoptotic Role of the Regulatory Feedback Loop between miR-124 and PKM1/HNF4α in Colorectal Cancer Cells
- Y. Sun, Xiaoping Zhao, +6 authors Yu Hu
- Biology, MedicineInternational journal of molecular sciences
- 1 March 2014
The data indicate that miR-124 not only alters the expression of genes involved in glucose metabolism but also stimulates cancer cell apoptosis, suggesting that disrupting this regulatory circuit might be a potential therapeutic tool for colorectal cancer treatment.
HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer
It is reported that HDAC1 expression was elevated in cancerous tissue and correlated with lymph node metastasis and poorer overall survival in patients with GBC, and there is a positive correlation betweenHDAC1 and TCF-12 which leading the high invasion and migration ability of GBC cells.
Expression profile of microRNAs in gastrointestinal stromal tumors revealed by high throughput quantitative RT-PCR microarray.
- H. Tong, Yuhong Zhou, +11 authors W. Lu
- Biology, MedicineWorld journal of gastroenterology
- 21 May 2015
The identified miRNAs appear to be novel biomarkers to distinguish malignant from benign GISTs, which may be helpful to understand the mechanisms of Gist oncogenesis and progression, and to further elucidate the characteristics of GIST subtypes.