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PF 04475270

Known as: PF-04475270, PF04475270 
National Institutes of Health

Papers overview

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2009
2009
Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models.
2009
2009
Pharmacokinetic-Pharmacodynamic and Response Sensitization Modeling of the Intraocular Pressure-Lowering Effect of the EP4 Agonist 5-{3-[(2S)-2-{(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]butyl}-5…
Developing a population-based pharmacokinetic-pharmacodynamic (PKPD) model is a challenge in ophthalmology due to the difficulty… 
2009
2009
Corneal Neovascularization and Ocular Irritancy Responses in Dogs Following Topical Ocular Administration of an EP4-Prostaglandin E2 Agonist
Prostaglandin receptor agonists have intraocular pressure–lowering effects in humans and are of interest in the treatment of… 
2009
2009
Ocular Hypotensive Activity and Pharmacokinetics of PF-04475270, an EP4 Prostaglandin Agonist in Preclinical Models
2009
2009
Effects of a Prodrug of a Prostanoid EP4 Receptor Agonist (PF-04475270) on Intraocular Pressure in Monkeys With Unilateral Glaucoma
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