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Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin F2α agonist, in preclinical models.
BOL-303259-X lowered intraocular pressure more effectively than latanoprost presumably as a consequence of a contribution by NO in addition to its prostaglandin activity, and is now in clinical development for the treatment of glaucoma and ocular hypertension. Expand
Aqueous humor dynamics in the aging human eye.
In the healthy aging eye, there is a Reduction in the production of aqueous humor and a reduction in its drainage through the uveoscleral outflow pathway. Expand
Update on the mechanism of action of topical prostaglandins for intraocular pressure reduction.
Recent animal and clinical studies of the effects of topical prostaglandin analogs on aqueous humor dynamics and recent cellular and molecular studies designed to clarify the outflow effects are summarized. Expand
Hydrostatic pressure of the suprachoroidal space.
The hydrostatic pressure of the suprachoroidal space was measured in 18 cynomolgus monkey eyes by one of two methods: direct cannulation, or silicone sponge implantation, and the pressure difference between the anterior chamber and the posterior supraciliary space increased at higher IOP. Expand
Effects of exogenous prostaglandins on aqueous humor dynamics and blood-aqueous barrier function.
In vitro and in vivo studies of the effects of PGs on aqueous humor dynamics and BAB integrity in humans, cats and monkeys indicate that PGs may directly modulate extracellular matrix metabolism, which may be related to the increased uveoscleral drainage. Expand
Morphology of ganglion cells in the neotenous tiger salamander retina
The morphology of retinal ganglion cells in the neotenous tiger salamander (Ambystoma tigrinum) was analyzed with the aid of morphometric techniques to determine the diversity of cell types and toExpand
Consensus recommendations for trabecular meshwork cell isolation, characterization and culture.
Having a set of standard practices for TM cells will increase the scientific rigor when used as a model, and enable other researchers to replicate and build upon previous findings. Expand
Aqueous Humor Dynamics in Ocular Hypertensive Patients
The increased IOP in ocular hypertensive patients is caused by a reduction in trabecular outflow facility and uveoscleral outflow and when both ocular normotensive and hypertensive groups are combined, aqueous flow and anterior chamber volume decrease slightly with age. Expand
PRDX6 attenuates oxidative stress- and TGFβ-induced abnormalities of human trabecular meshwork cells
It is demonstrated that peroxiredoxin (PRDX) 6, an antioxidant, offsets the deleterious effects of oxidative stress on TM cells by optimizing ROS and TGFβ levels and provides a foundation for antioxidant-based therapeutics for treating glaucoma. Expand
Effects of brimonidine on aqueous humor dynamics in human eyes.
The brimonidine-induced reduction in IOP in humans is associated with a decrease in aqueous flow and an increase in uveoscleral outflow, which suggests a mild contralateral effect. Expand