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PF 03084014

Known as: PF-03084014, PF03084014 
National Institutes of Health

Papers overview

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2018
2018
Combined Erlotinib and PF‐03084014 treatment contributes to synthetic lethality in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is characterized by high mortality and low survival rates. As an epidermal growth… 
2016
2016
Activity of PF-03084014 in adults with desmoid tumors/aggressive fibromatosis.
11028Background: Desmoids are rare, locally invasive, slow growing soft tissue tumors that are either sporadic or associated with… 
2015
2015
Phase I dose-finding study of the gamma secretase inhibitor PF-03084014 (PF-4014) in combination with docetaxel in patients (pts) with advanced triple-negative breast cancer (TNBC).
1068 Background: Gamma secretase is a key component of the Notch signaling pathway, which is involved in cancer cell biology and… 
2014
2014
New, Tolerable γ-Secretase Inhibitor Takes Desmoid Down a Notch
A phase I trial of PF-03084014, an oral reversible γ-secretase inhibitor, in solid tumor malignancies shows drug tolerability in… 
2014
2014
Initial testing (stage 1) of the notch inhibitor PF‐03084014, by the pediatric preclinical testing program
PF‐03084014, a γ‐secretase inhibitor, was tested against the PPTP in vitro cell line panel (1.0 nM to 10 μM) and against the in… 
2014
2014
Endocrine therapy resistance and epithelial to mesenchymal transition are driven by Nicastrin and Notch4 cooperation in MCF7 breast cancer cells.
Endocrine therapy resistant (ETR) tumors often display mesenchymal features, associated with aggressive and enhanced motility… 
2012
2012
Abstract 3492: γ-secretase inhibitor PF-03084014 diminishes the tumor-initiating cells and demonstrates synergy with docetaxel in breast cancer xenograft models
Notch signaling is known to be a survival pathway for tumor-initiating cells. In this report, we demonstrate that the γ-secretase… 
2011
2011
A phase I dose-escalation study of the novel gamma secretase inhibitor PF-03084014 in patients (pts) with advanced solid tumors.
3100 Background: Aberrant Notch signaling is implicated in tumor genesis. Gamma secretase plays a key role in Notch-dependent… 
2011
2011
Reversal of glucocorticoid resistance by the g-secretase inhibitor PF-03084014 in T-cell acute lymphoblastic leukemia.
9553 Background: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer frequently characterized by… 
2010
2010
Mitigation of goblet cell hyperplasia and gastrointestinal toxicity in rats with intermittent combination dosing of PF-03084014 (gamma secretase inhibitor) and dexamethasone.
e13616 Background: Gamma-secretase inhibitors (GSIs), which block activation of the oncogenic protein Notch homolog-1 (NOTCH-1… 
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