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PF 03084014
Known as:
PF-03084014
, PF03084014
National Institutes of Health
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Papers overview
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2018
2018
Abstract P6-07-06: Targeting cancer stem-like cells metabolism via non-canonical notch signaling pathways in triple negative breast cancer
Fokhrul M. Hossain
,
C. Sorrentino
,
+7 authors
L. Miele
2018
Corpus ID: 79640849
Triple negative breast cancer (TNBC) is a heterogeneous group of clinically aggressive diseases. TNBC patients have high risk of…
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2016
2016
Abstract 4116: Anti-tumor and anti-metastasis efficacy of a novel Notch inhibitor (PF-03084014) in hepatocellular carcinoma
Chuan-Xing Wu
,
Xiao-Qi Wang
2016
Corpus ID: 79297586
2012
2012
Cancer Therapy : Preclinical Biomarker and Pharmacologic Evaluation of the g-Secretase Inhibitor PF-03084014 in Breast Cancer Models
C. Zhang
,
A. Pavlícek
,
+13 authors
J. Christensen
2012
Corpus ID: 26996647
Purpose: We aimed to assess the biologic activity of PF-03084014 in breast xenograft models. The biomarkers for mechanism and…
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2012
2012
Preclinical Development Preclinical Analysis of the g-Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia
J. Samon
,
M. Castillo-Martin
,
+9 authors
A. Ferrando
2012
Corpus ID: 6011790
T-cell acute lymphoblastic leukemias (T-ALL) and lymphomas are aggressive hematologic cancers frequently associated with…
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2011
2011
Abstract 5190: Biomarkers of sensitivity to PF-03084014, a γ-secretase Inhibitor, in a preclinical model of colorectal cancer
R. Powell
,
A. Tan
,
+8 authors
J. Arcaroli
2011
Corpus ID: 76304101
Purpose: To evaluate the efficacy of PF-03084014, a γ-secretase inhibitor, in a preclinical model of colorectal cancer (CRC) and…
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2010
2010
Abstract 5218: γ-secretase inhibitor PF-03084014 impairs Notch signaling and induces antiangiogenic and antitumor effects in breast cancer models
C. Zhang
,
Qin Zhang
,
+14 authors
J. Christensen
2010
Corpus ID: 74849107
PF-03084014, a small molecule γ-secretase inhibitor (GSI), has previously been shown to inhibit Notch signaling and demonstrated…
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2010
2010
Mitigation of goblet cell hyperplasia and gastrointestinal toxicity in rats with intermittent combination dosing of PF-03084014 (gamma secretase inhibitor) and dexamethasone.
B. Han
,
L. Liu
,
R. Denlinger
,
N. Hosea
,
L. B. Naas
,
S. Randolph
2010
Corpus ID: 74688336
e13616 Background: Gamma-secretase inhibitors (GSIs), which block activation of the oncogenic protein Notch homolog-1 (NOTCH-1…
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