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PDK4 gene

Known as: pyruvate dehydrogenase kinase 4, Pyruvate Dehydrogenase Kinase, Isozyme 4 Gene, PYRUVATE DEHYDROGENASE KINASE, ISOENZYME 4 
This gene plays a role in the regulation of glucose and fatty acid metabolism.
National Institutes of Health

Related topics

Related topics

8 relations
Carbohydrate MetabolismEnergy MetabolismPDK4 protein, humanPhosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity.
2019
2019
High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases
Patients with borderline resectable colorectal liver metastases (CRLM) frequently receive neoadjuvant chemotherapy (NC) to reduce… 
2018
2018
Dietary supplementation with alkylresorcinols prevents muscle atrophy through a shift of energy supply.
2016
2016
Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer*
Drug resistance is one of the main causes of colon cancer recurrence. However, our understanding of the underlying mechanisms and… 
2016
2016
A Comparative Docking Studies of Dichloroacetate Analogues on Four Isozymes of Pyruvate Dehydrogenase Kinase in Humans
Introduction: The four Pyruvate dehydrogenase kinases (PDKs) that regulate the mammalian Pyruvate dehydrogenase complex (PDC) are… 
2012
2012
Adipocyte pyruvate dehydrogenase kinase 4 expression is associated with augmented PPARγ upregulation in early-life programming of later obesity
2012
2012
Activating cardiac E2F1 induces up‐regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding
2010
2010
PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle.
The aim of this study was to test whether the transcriptional coactivator peroxisome proliferator-activated receptor (PPAR… 
2009
2009
Adiponectin decreases pyruvate dehydrogenase kinase 4 gene expression in obese‐ and diabetic‐derived myotubes
Aim:  To investigate the effects of globular adiponectin (gAd) on gene expression and whether these effects are mediated through… 
Highly Cited
2005
Highly Cited
2005
Cloning of the Rat Pyruvate Dehydrogenase Kinase 4 Gene Promoter
The pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl-CoA in mitochondria and is a key regulatory… 
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