PDK4 gene

Known as: pyruvate dehydrogenase kinase 4, Pyruvate Dehydrogenase Kinase, Isozyme 4 Gene, PYRUVATE DEHYDROGENASE KINASE, ISOENZYME 4 
This gene plays a role in the regulation of glucose and fatty acid metabolism.
National Institutes of Health

Papers overview

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2013
2013
The renin-angiotensin system (RAS) may alter cardiac energy metabolism in heart failure. Angiotensin II (ANG II), the main… (More)
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Highly Cited
2012
Highly Cited
2012
DNA methylation is a covalent biochemical modification controlling chromatin structure and gene expression. Exercise elicits gene… (More)
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2010
2010
The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate to acetyl-CoA in mitochondria and is a key… (More)
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Highly Cited
2006
Highly Cited
2006
We previously showed that insulin has a profound effect to suppress pyruvate dehydrogenase kinase (PDK) 4 expression in rat… (More)
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Highly Cited
2005
Highly Cited
2005
The transcriptional coactivator PGC-1alpha is a key regulator of energy metabolism, yet little is known about its role in control… (More)
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Highly Cited
2003
Highly Cited
2003
A forkhead-type transcription factor, DAF-16, is located in the most downstream part of the insulin signalling pathway via PI3K… (More)
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Highly Cited
2003
Highly Cited
2003
During short-term fasting, substrate utilization in skeletal muscle shifts from predominantly carbohydrate to fat as a means of… (More)
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Highly Cited
2002
Highly Cited
2002
Hibernation in mammals requires a metabolic shift away from the oxidation of carbohydrates and toward the combustion of stored… (More)
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Highly Cited
2002
Highly Cited
2002
Transcription of metabolic genes is transiently induced during recovery from exercise in skeletal muscle of humans. To determine… (More)
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Highly Cited
2000
Highly Cited
2000
Exercise training elicits a number of adaptive changes in skeletal muscle that result in an improved metabolic efficiency. The… (More)
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