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PDGFRA gene

Known as: PDGFR2, CD140a, GAS9 
This gene plays a role in mitogenic activities affecting mesenchymal cells and is involved in receptor tyrosine kinase signal transduction.
National Institutes of Health

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Related topics

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Benign Epithelioid Cell Type Gastrointestinal Stromal TumorBenign Gastrointestinal Stromal TumorCell ProliferationChronic Eosinophilic Leukemia with FIP1L1-PDGFRA

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PDGFRA wt Allele

Papers overview

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2015
2015
Analysis of mutation of the c-Kit gene and PDGFRA in gastrointestinal stromal tumors.
The aim of the present study was to investigate mutation status of the c-Kit gene (KIT) and PDGFRA in patients with a… 
2015
2015
Presence of PDGFRA and DOG1 mutations in gastrointestinal stromal tumors among Chinese population.
Approximately 15% of gastrointestinal stromal tumors (GIST) do not express KIT mutations and of these about 5 to 7% harbor… 
Review
2015
Review
2015
Myxoid epithelioid gastrointestinal stromal tumor harboring an unreported PDGFRA mutation: report of a case and review of the literature.
Activating mutations of platelet-derived growth factor receptor α (PDGFRA) are detected in a significant proportion of… 
2011
2011
Validation of a high-content screening assay using whole-well imaging of transformed phenotypes.
Automated microscopy was introduced two decades ago and has become an integral part of the discovery process as a high-content… 
2010
2010
[Gastrointestinal stromal tumor (GIST)--medical rarities?].
Although their overall incidence is low, GISTs are distinctive subgroup of gastrointestinal mesenchymal tumors which express… 
2009
2009
Successes and Challenges in Translational Research: The Development of Targeted Therapy for Gastrointestinal Stromal Tumours
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms that most commonly affect the stomach or small intestine, but… 
Highly Cited
2008
Highly Cited
2008
Primary multiple extragastrointestinal stromal tumors of the omentum with different mutations of c-kit gene.
The author reports a very rare case of sporadic primary multiple extragastrointestinal stromal tumors (EGISTs) of the omentum… 
2008
2008
[Status and clinical analysis of c-kit and PDGFRA mutations in the gastrointestinal stromal tumors].
OBJECTIVE To investigate the status of c-kit and PDGFRA mutations in the gastrointestinal stromal tumors (GIST) and explore the… 
2006
2006
[Status and clinical implication of c-kit and PDGFRA mutations in 165 cases of gastrointestinal stromal tumor (GIST)].
OBJECTIVE To investigate the status of c-kit and PDGFRA mutations of GIST in a the large sample of Chinese patients. METHOD One… 
2005
2005
[c-kit and PDGFRA mutations in 60 cases of gastrointestinal stromal tumors (GISTs)].
OBJECTIVE To explore the status of activating mutations of c-kit and PDGFRA in GIST of Chinese patients. METHODS Sixty GISTs… 
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