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PDGFRA gene
Known as:
PDGFR2
, CD140a
, GAS9
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This gene plays a role in mitogenic activities affecting mesenchymal cells and is involved in receptor tyrosine kinase signal transduction.
National Institutes of Health
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Related topics
Related topics
31 relations
Benign Epithelioid Cell Type Gastrointestinal Stromal Tumor
Benign Gastrointestinal Stromal Tumor
Cell Proliferation
Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA
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PDGFRA wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Abstract 3925: Inhibition of oncogenic and drug-resistant PDGFRA and KIT alterations by DCC-2618
Bryan D. Smith
,
Michael D. Kaufman
,
+8 authors
D. Flynn
Experimental and Molecular Therapeutics
2018
Corpus ID: 81379062
Introduction: Activating mutations and other genetic alterations in KIT and PDGFRA receptor tyrosine kinases have been identified…
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2017
2017
Abstract 1136: Heat shock protein 90 inhibitors suppress PDGFRA reactivation and other receptor tyrosine kinase activation important in drug resistant gastrointestinal stromal tumors
M. Yamamura
,
A. Yamauchi
,
+5 authors
Y. Yamaguchi
2017
Corpus ID: 79883511
2015
2015
Mutational profile of KIT and PDGFRA genes in gastrointestinal stromal tumors in Peruvian samples.
J. Buleje
,
Oscar Acosta
,
+5 authors
R. Fujita
Revista Espanola de Enfermedades Digestivas
2015
Corpus ID: 20872388
INTRODUCTION Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms usually caused by somatic mutations in the genes…
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2013
2013
Abstract P6-12-15: Preclinical testing of a novel platelet derived growth factor receptor alpha (PDGFRa) inhibitor in inflammatory breast cancer
M. Joglekar
,
S. Laere
,
+4 authors
Kl van Golen
2013
Corpus ID: 71601497
Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer and carries a guarded prognosis. IBC…
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2013
2013
Molecular and Cellular Pathobiology NovelOncogenic PDGFRA Mutations inPediatricHighGrade inPediatricHighGrade inPediatricHighGrade Gliomas
Barbara S. Paugh
,
Xiaoyan Zhu
,
+13 authors
S. Baker
2013
Corpus ID: 19149975
The outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year survival rate of only 10% to 30%. Diffuse…
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2011
2011
Abstract 5474: Optimization of a microdialysis method for evaluation of CP-868,596 penetration in glioblastoma murine models using a sensitive liquid chromatography mass spectrometry (LC-MS/MS…
M. Elmeliegy
,
Feng Bai
,
Stephen J. Juel
,
S. Throm
,
A. Ramachandran
,
C. Stewart
2011
Corpus ID: 72535310
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Focal amplification and gene rearrangement of the…
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2008
2008
Caracterização clinicopatológica, imunoistoquímica e genética molecular do tumor estromal gastrintestinal no Brasil
L. Lopes
2008
Corpus ID: 82330050
2008
2008
Combination of PKC412 and sirolimus in a metastatic patient with PDGFRA-D842V gastrointestinal stromal tumor (GIST)
E. Palassini
,
E. Fumagalli
,
+4 authors
P. Casali
2008
Corpus ID: 74643703
21515 Background: The exon 18 PDGFRA-D842V mutation is the most common PDGFRA mutation in GIST. This mutation appears to be…
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2005
2005
Gastrointestinal stromal tumors. Pathogenetic mechanisms, phenotypic characterization and prognosis
J. Andersson
2005
Corpus ID: 54846583
GASTROINTESTINAL STROMAL TUMORS PATHOGENETIC MECHANISMS, PHENOTYPIC CHARACTERIZATION AND PROGNOSIS Johanna Andersson Lundberg…
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1996
1996
Assignment ofc-KIT gene to swine Chromosome 8pl2-p21 by fluorescence in situ hybridization
M. Sakurai
,
J. H. Zhou
,
M. Ohtaki
,
T. Itoh
,
Y. Murakami
,
H. Yasue
Mammalian Genome
1996
Corpus ID: 31946003
Species: Pig (Sus scrofa domestica) Locus name: Hardy-Zuckerman 4 feline sarcoma viral (v-KIT) oncogene homolog Locus symbol: KIT…
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