FAQ

PDGFA gene

Known as: PDGF-A, PDGF A-chain, PDGFA 
This gene plays a role in cellular growth and proliferation. It is also involved in intercellular signaling.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2018
0102019862018

Related topics

Related topics

8 relations
Cell ProliferationCell Proliferation Regulatory ProcessHomo sapiensIntercellular Communication Process
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
PDGFA gene
Wound Healing
Cell Proliferation
Homo sapiens
Intercellular Communication Process
Cell Proliferation Regulatory Process

Papers overview

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2012
2012
Overexpression of PDGFA and its receptor during carcinogenesis of Opisthorchis viverrini-associated cholangiocarcinoma.
Cholangiocarcinoma (CCA) is a crucial health problem in northeastern part of Thailand, which is caused by a combination of… (More)
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2009
2009
Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas
Background:Malignant gliomas are the most prevalent type of primary brain tumours but the therapeutic armamentarium for these… (More)
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2008
2008
High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF.
PURPOSE Pancreatic cancer still has one of the worst prognoses in gastrointestinal cancers with a 5-year survival rate of 5… (More)
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2008
2008
Distinct gene expression-defined classes of gastrointestinal stromal tumor.
PURPOSE The majority of gastrointestinal stromal tumors (GIST) can be cured by surgery alone, but relapse occurs in 20% to 40% of… (More)
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1997
1997
Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3.
Platelet-derived growth factor (PDGF) A-chain is expressed by vascular smooth muscle cells (SMC) in a variety of pathological… (More)
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1992
1992
Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences
The PDGFs are a family of molecules assembled as disulfide-bonded homo- and heterodimers from two distinct but highly homologous… (More)
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1992
1992
The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene.
The Wilms' tumor locus on chromosome 11p13 contains a tumor suppressor gene, wt1, which encodes a DNA binding protein (WT1) with… (More)
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1992
1992
The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22.
The human PDGFA gene has been mapped previously to two different sites on chromosome 7 (7p21----p22 and 7q11.2----q21.1). Using… (More)
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1991
1991
PDGF A-chain gene is expressed by mammalian neurons during development and in maturity.
Platelet-derived growth factor (PDGF) may be a critical factor in the temporal differentiation of glial elements in the mammalian… (More)
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Highly Cited
1989
Highly Cited
1989
Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA.
Both interleukin-1 (IL-1) and platelet-derived growth factor (PDGF) induce proliferation of cultured fibroblasts and smooth… (More)
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