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PDE5A gene

Known as: PDE5A, PHOSPHODIESTERASE 5A, Phosphodiesterase 5A, cGMP-Specific Gene 
This gene plays a role in signaling.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Cyclic guanosine monophosphate (cGMP) is a second messenger molecule that transduces nitric-oxide- and natriuretic-peptide… Expand
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Highly Cited
2011
Highly Cited
2011
We show that in melanoma cells oncogenic BRAF, acting through MEK and the transcription factor BRN2, downregulates the cGMP… Expand
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Review
2007
Review
2007
Phosphodiesterase type 5A (PDE5A) selectively hydrolyzes cyclic GMP. Inhibitors of PDE5A such as sildenafil are widely used to… Expand
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Highly Cited
2007
Highly Cited
2007
Pulmonary hypertension (PHT) is associated with increased vascular resistance due to sustained contraction and enhanced… Expand
Highly Cited
2005
Highly Cited
2005
Sustained cardiac pressure overload induces hypertrophy and pathological remodeling, frequently leading to heart failure… Expand
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Highly Cited
2004
Highly Cited
2004
Phosphodiesterases (PDEs) comprise a large family of enzymes that catalyze the hydrolysis of cAMP or cGMP and are implicated in… Expand
Highly Cited
2004
Highly Cited
2004
Phosphodiesterases (PDEs) comprise a family of enzymes that modulate the immune response, inflammation, and memory, among many… Expand
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Highly Cited
2003
Highly Cited
2003
Inducible nitric oxide synthase (iNOS) is expressed in both the fibrotic plaque of Peyronie's disease (PD) in the human, and in… Expand
Highly Cited
2001
Highly Cited
2001
Recent studies implicate increased cGMP synthesis as a postreceptor contributor to reduced cardiac sympathetic responsiveness… Expand
Highly Cited
1998
Highly Cited
1998
We have cloned and characterized the first human isozyme in a new family of cyclic nucleotide phosphodiesterases, PDE9A. By… Expand