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PDE5A gene

Known as: PDE5A, PHOSPHODIESTERASE 5A, Phosphodiesterase 5A, cGMP-Specific Gene 
This gene plays a role in signaling.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
We show that in melanoma cells oncogenic BRAF, acting through MEK and the transcription factor BRN2, downregulates the cGMP… Expand
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Highly Cited
2010
Highly Cited
2010
Phosphodiesterase type 5A (PDE5A) inhibitors acutely suppress beta-adrenergic receptor (β-AR) stimulation in left ventricular… Expand
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Highly Cited
2008
Highly Cited
2008
Pulmonary hypertension frequently complicates interstitial lung disease, where it is associated with a high mortality. Patients… Expand
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Pulmonary hypertension (PH) secondary to left heart failure portends a poor prognosis and is a relative… Expand
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Highly Cited
2005
Highly Cited
2005
Sustained cardiac pressure overload induces hypertrophy and pathological remodeling, frequently leading to heart failure… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Sildenafil inhibits phosphodiesterase 5 (PDE5A) to elevate intracellular cGMP and to induce vasodilation. This effect… Expand
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Highly Cited
2003
Highly Cited
2003
Inducible nitric oxide synthase (iNOS) is expressed in both the fibrotic plaque of Peyronie's disease (PD) in the human, and in… Expand
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2002
2002
Sildenafil improves erectile function by inhibiting the cGMP-catalytic activity of phosphodiesterase type V (PDE5). We used rapid… Expand
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2001
2001
PDE5A gene encodes type 5 phosphodiesterase (PDE5), the principal cGMP-catalyzing enzyme in the penis and the primary target of… Expand
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Highly Cited
1998
Highly Cited
1998
cGMP-binding, cGMP-specific phosphodiesterase which is encoded by the PDE5A gene plays important roles in cardiovascular system… Expand
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