PDE5A gene

Known as: PDE5A, PHOSPHODIESTERASE 5A, Phosphodiesterase 5A, cGMP-Specific Gene 
This gene plays a role in signaling.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2018
051019952018

Papers overview

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Highly Cited
2011
Highly Cited
2011
We show that in melanoma cells oncogenic BRAF, acting through MEK and the transcription factor BRN2, downregulates the cGMP… (More)
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2010
2010
Phosphodiesterase type 5A (PDE5A) inhibitors acutely suppress beta-adrenergic receptor (β-AR) stimulation in left ventricular… (More)
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2007
2007
Aging-related erectile dysfunction is characterized by a loss of smooth muscle cells (SMCs) and fibrosis in the corpora cavernosa… (More)
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Highly Cited
2005
Highly Cited
2005
Sustained cardiac pressure overload induces hypertrophy and pathological remodeling, frequently leading to heart failure… (More)
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2004
2004
Phosphodiesterases (PDEs) comprise a family of enzymes that modulate the immune response, inflammation, and memory, among many… (More)
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Highly Cited
2003
Highly Cited
2003
Inducible nitric oxide synthase (iNOS) is expressed in both the fibrotic plaque of Peyronie's disease (PD) in the human, and in… (More)
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2002
2002
Sildenafil improves erectile function by inhibiting the cGMP-catalytic activity of phosphodiesterase type V (PDE5). We used rapid… (More)
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2001
2001
PDE5A gene encodes type 5 phosphodiesterase (PDE5), the principal cGMP-catalyzing enzyme in the penis and the primary target of… (More)
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Highly Cited
2001
Highly Cited
2001
Recent studies implicate increased cGMP synthesis as a postreceptor contributor to reduced cardiac sympathetic responsiveness… (More)
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1998
1998
cGMP-binding, cGMP-specific phosphodiesterase which is encoded by the PDE5A gene plays important roles in cardiovascular system… (More)
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