Cyclic Nucleotide Phosphodiesterases, Type 5

Known as: Phosphodiesterase-5, Cyclic Nucleotide Phosphodiesterases, Type 5 [Chemical/Ingredient], Phosphodiesterases, PDE5 
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an… (More)
National Institutes of Health

Papers overview

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Review
2013
Review
2013
OBJECTIVE To present a summary of the 2013 version of the European Association of Urology guidelines on the treatment and follow… (More)
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Highly Cited
2013
Highly Cited
2013
IMPORTANCE Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Sildenafil was recently approved for the treatment of pulmonary arterial hypertension. The beneficial effects of… (More)
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Highly Cited
2006
Highly Cited
2006
Phosphodiesterase-5 (PDE5) inhibitors (sildenafil, tadalafil, and vardenafil) are agents currently in clinical use for… (More)
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Highly Cited
2005
Highly Cited
2005
Sustained cardiac pressure overload induces hypertrophy and pathological remodeling, frequently leading to heart failure… (More)
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Highly Cited
2004
Highly Cited
2004
By real-time RT-PCR and Western blot analysis, we found that phosphodiesterase type 5 (PDE5) mRNA and protein abundance was… (More)
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Highly Cited
2000
Highly Cited
2000
In addition to its cGMP-selective catalytic site, cGMP-binding cGMP-specific phosphodiesterase (PDE5) contains two allosteric… (More)
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Highly Cited
2000
Highly Cited
2000
GAF domains are ubiquitous motifs present in cyclic GMP (cGMP)-regulated cyclic nucleotide phosphodiesterases, certain adenylyl… (More)
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Highly Cited
1999
Highly Cited
1999
Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE5), which has been shown to be a clinically effective… (More)
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Highly Cited
1998
Highly Cited
1998
PURPOSE Sildenafil, an inhibitor of cGMP-specific phosphodiesterase 5 (PDE5), is currently undergoing evaluation as an oral… (More)
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