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Cyclic Nucleotide Phosphodiesterases, Type 5

Known as: Phosphodiesterase-5, Cyclic Nucleotide Phosphodiesterases, Type 5 [Chemical/Ingredient], Phosphodiesterases, PDE5 
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an… 
National Institutes of Health

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In BloodPDE5A geneProcess of secretionaspects of radiation effects

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PDE5A protein, humanPde5a protein, mouse

Papers overview

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Review
2016
Review
2016
Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap
Heart failure (HF) with preserved ejection fraction (EF; HFpEF) accounts for 50% of HF cases, and its prevalence relative to HF… 
Review
2014
Review
2014
A systematic review of the association between erectile dysfunction and cardiovascular disease.
Review
2009
Review
2009
Updated evidence-based treatment algorithm in pulmonary arterial hypertension.
Highly Cited
2007
Highly Cited
2007
Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility
Background— Sildenafil was recently approved for the treatment of pulmonary arterial hypertension. The beneficial effects of… 
Highly Cited
2005
Highly Cited
2005
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
Sustained cardiac pressure overload induces hypertrophy and pathological remodeling, frequently leading to heart failure… 
Highly Cited
2005
Highly Cited
2005
Phosphodiesterase-5 Inhibitor Sildenafil Preconditions Adult Cardiac Myocytes against Necrosis and Apoptosis
We investigated the effect of sildenafil in protection against necrosis or apoptosis in cardiomyocytes. Adult mouse ventricular… 
Highly Cited
2002
Highly Cited
2002
Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses.
Highly Cited
2001
Highly Cited
2001
Sildenafil Inhibits Hypoxia-Induced Pulmonary Hypertension
Background— This study investigated the effect of the phosphodiesterase 5 inhibitor sildenafil on the pulmonary vascular response… 
Highly Cited
1998
Highly Cited
1998
Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes.
Highly Cited
1998
Highly Cited
1998
Clinical safety of oral sildenafil citrate (VIAGRATM) in the treatment of erectile dysfunction
Sildenafil citrate has been shown to be effective in a wide range of patients with erectile dysfunction and has been approved in… 
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