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PDE4B gene

Known as: phosphodiesterase E4 dunce homolog (Drosophila), phosphodiesterase 4B, DUNCE-LIKE PHOSPHODIESTERASE E4, FORMERLY 
This gene plays a role in the metabolism of cyclic AMP.
National Institutes of Health

Related topics

Related topics

4 relations
HydrolysisPDE4B protein, humanSignal Transductionphosphodiesterase 4B

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain.
Review
2014
Review
2014
Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease
Between 20% and 25% of patients diagnosed with Alzheimer’s disease (AD) do not have amyloid burden as assessed by positron… 
Highly Cited
2012
Highly Cited
2012
ZNF804a Regulates Expression of the Schizophrenia-Associated Genes PRSS16, COMT, PDE4B, and DRD2
ZNF804a was identified by a genome-wide association study (GWAS) in which a single nucleotide polymorphism (SNP rs1344706) in… 
Highly Cited
2008
Highly Cited
2008
PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia
Review
2007
Review
2007
Role of DISC1 in neural development and schizophrenia
Highly Cited
2005
Highly Cited
2005
RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor…
PDE4B and PDE4D provide >90% of PDE4 cAMP phosphodiesterase activity in human embryonic kidney (HEK293B2) cells. Their selective… 
Highly Cited
2005
Highly Cited
2005
The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma.
Diffuse large B-cell lymphoma (DLBCL) is a common and often fatal malignancy. Advances in the treatment of this disease will… 
Highly Cited
2002
Highly Cited
2002
Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis.
A combination of pharmacological and genetic approaches was used to determine the role of type 4 cAMP-specific cyclic nucleotide… 
Highly Cited
2002
Highly Cited
2002
Regulation of cAMP phosphodiesterase mRNAs expression in rat brain by acute and chronic fluoxetine treatment. An in situ hybridization study
Highly Cited
1999
Highly Cited
1999
Suppression of human inflammatory cell function by subtype‐selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B
Of the four major phosphodiesterase 4 (PDE4) subtypes, PDE4A, PDE4B and PDE4D are widely expressed in human inflammatory cells… 
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