PDE4B gene

Known as: phosphodiesterase E4 dunce homolog (Drosophila), phosphodiesterase 4B, DUNCE-LIKE PHOSPHODIESTERASE E4, FORMERLY 
This gene plays a role in the metabolism of cyclic AMP.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2018
0102019952018

Papers overview

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2012
2012
ZNF804a was identified by a genome-wide association study (GWAS) in which a single nucleotide polymorphism (SNP rs1344706) in… (More)
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2012
2012
Disrupted-In-Schizophrenia-1 (DISC1) is a strong genetic risk factor associated with psychiatric disorders. Two distinct… (More)
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2008
2008
Schizophrenia has a complex genetic underpinning and variations in a number of candidate genes have been identified that confer… (More)
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Highly Cited
2008
Highly Cited
2008
Phosphodiesterase-4 (PDE4), an enzyme that catalyzes the hydrolysis of cyclic AMP and plays a critical role in controlling its… (More)
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2007
2007
BACKGROUND Phosphodiesterase 4B (PDE4B) is a candidate gene for schizophrenia and affective disorders through its disruption by a… (More)
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Highly Cited
2005
Highly Cited
2005
The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role in… (More)
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Highly Cited
2005
Highly Cited
2005
PDE4B and PDE4D provide >90% of PDE4 cAMP phosphodiesterase activity in human embryonic kidney (HEK293B2) cells. Their selective… (More)
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Highly Cited
2005
Highly Cited
2005
Diffuse large B-cell lymphoma (DLBCL) is a common and often fatal malignancy. Advances in the treatment of this disease will… (More)
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2002
Highly Cited
2002
Lipopolysaccharide (LPS) stimulation of the innate immune response requires the activation of signaling cascades that culminate… (More)
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Highly Cited
2000
Highly Cited
2000
We have examined the distribution of four different cyclic AMP-specific phosphodiesterase isozyme (PDE4A, PDE4B, PDE4C and PDE4D… (More)
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