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Identification of new therapeutic targets may improve the survival rate of patients with colorectal cancer (CRC). Recent studies… Expand High-fat-diet (HFD) feeding induces adipose dysfunction. This study aims to explore whether the Traditional Chinese Medical… Expand Traumatic brain injury (TBI) initiates a deleterious inflammatory response that exacerbates pathology and worsens outcome. This… Expand DNA damage is an important contributor to endothelial dysfunction and age-related vascular disease. Recently, we demonstrated in… Expand Learning and memory impairments are common in traumatic brain injury (TBI) survivors. However, there are no effective treatments… Expand Phosphodiesterase 4 (PDE4) is an adenosine cyclic 3,5-monophosphate-specific degradative enzyme, which is closely associated with… Expand Abstract Phosphodiesterase 4B (PDE4B) is a member of the phosphodiesterase family of proteins that plays a critical role in… Expand OBJECTIVE To observe the preliminary action of phosphodiesterase 4B(PDE4B) in bleomycin-induced pulmonary fibrosis in mice… Expand Background: Mucus overproduction is a hallmark of otitis media (OM) induced by Streptococcus pneumoniae. Results: PDE4B mediates… Expand Identification of rational therapeutic targets is an important strategy to improve the cure rate of diffuse large B-cell lymphoma… Expand