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PD 166326

Known as: PD166326 
 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Imatinib is used to treat chronic myelogenous leukemia (CML), but resistance develops in all phases of this disease. The purpose… Expand
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2007
2007
Imatinib targets the Bcr-Abl oncogene that causes chronic myelogenous leukemia (CML) in humans. Recently, we demonstrated that… Expand
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Highly Cited
2006
Highly Cited
2006
Mutation in the ABL kinase domain is the principal mechanism of imatinib resistance in patients with chronic myelogenous leukemia… Expand
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Review
2006
Review
2006
Imatinib mesylate, Abl tyrosine kinase inhibitor, has improved the treatment of Bcr-Abl-positive leukemia such as chronic myeloid… Expand
Highly Cited
2005
Highly Cited
2005
In Philadelphia-positive (Ph(+)) leukemia, point mutations within the Bcr-Abl kinase domain emerged as a major mechanism of… Expand
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Highly Cited
2005
Highly Cited
2005
Imatinib mesylate is highly effective in newly diagnosed chronic myeloid leukemia (CML), but BCR/ABL (breakpoint cluster region… Expand
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2005
2005
Abl inhibitor BMS354825 binding mode in Abelson kinase revealed by molecular docking studies 
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Highly Cited
2003
Highly Cited
2003
Inhibition of the constitutively active Bcr-abl tyrosine kinase(TK) by STI571 has proven to be a highly effective treatment for… Expand
Highly Cited
2003
Highly Cited
2003
Imatinib mesylate (STI571, Glivec), a 2-phenylaminopyrimidine small-molecule ATP competitor-type kinase inhibitor, proved to be… Expand
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Highly Cited
2002
Highly Cited
2002
The early stage of chronic myelogenous leukemia (CML) is caused by the tyrosine kinase Bcr-Abl. Imatinib mesylate (also known as… Expand
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