PD 0325901

Known as: PD325901, PD-0325901, PD 325901 
An orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential… (More)

Topic mentions per year

Topic mentions per year

2004-2018
0204020042018

Papers overview

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Highly Cited
2012
Highly Cited
2012
Recently, strategies for acute myeloid leukemia (AML) therapy have been developed that target anti-apoptotic BCL2 family members… (More)
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Highly Cited
2011
Highly Cited
2011
Genetic reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) could offer replenishable cell sources for… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE To determine tolerability, pharmacokinetics, and pharmacodynamics of PD-0325901, a highly potent, selective, oral mitogen… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE To evaluate the efficacy of mitogen-activated protein kinase/extracellular signal-related kinase kinase inhibitor PD… (More)
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Highly Cited
2009
Highly Cited
2009
Mutational activation of BRAF is the earliest and most common genetic alteration in human melanoma. To build a model of human… (More)
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Highly Cited
2008
Highly Cited
2008
A novel series of benzhydroxamate esters derived from their precursor anthranilic acids have been prepared and have been… (More)
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Highly Cited
2008
Highly Cited
2008
The AKT/mammalian target of rapamycin (AKT/mTOR) and ERK MAPK signaling pathways have been shown to cooperate in prostate cancer… (More)
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Highly Cited
2008
Highly Cited
2008
CONTEXT Mutually exclusive mutations of RET, RAS, or BRAF are present in about 70% of papillary thyroid carcinomas, whereas only… (More)
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Highly Cited
2007
Highly Cited
2007
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE This multicenter, open-label, phase II study was undertaken to assess the antitumor activity and safety of the oral… (More)
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