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PD 0325901

Known as: PD325901, PD-0325901, PD 325901 
An orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential… 
National Institutes of Health

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Related topics

4 relations

Broader (2)

BenzamidesDiphenylamine
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Derivation of Mouse Embryonic Stem (ES) Cell Lines Using Small-Molecule Inhibitors of Erk and Gsk3 Signaling (2i).
The efficiency of embryonic stem (ES) cell derivation is very high if embryos are incubated, from the eight-cell stage, in the… 
2017
2017
Jmjd 2 c / Kdm 4 c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation
Jmjd2/Kdm4 H3K9-demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity. However, little is known about… 
2015
2015
KD 1 is downregulated in non-small cell lung cancer andmediates the eedback inhibition of mTORC 1S 6 K 1 axis in response to phorbol ester
Protein kinase D1 (PKD1) is increasingly implicated in multiple biological and molecular events that regulate the proliferation… 
Review
2015
Review
2015
The Role of the Tumor Microenvironment and Epithelial-Mesenchymal Plasticity in Prostate Cancer Progression and Metastasis
PTEN is one of the most commonly deleted tumor suppressor genes in human prostate cancer. Our group previously demonstrated that… 
2014
2014
Cancer Therapy : Preclinical Cotargeting the PI 3 K and RAS Pathways for the Treatment of Neuroendocrine Tumors
Background: The precise involvement of the PI3K/mTOR andRAS/MEKpathways in carcinoid tumors is not well defined. Therefore, the… 
2013
2013
Abstract 5521: Application of an automated capillary isoelectric-focusing immunoassay to study dynamic oncoprotein phosphorylation in non-small cell lung cancer and for evaluating drug response to…
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Molecular targeted therapy is widely used to treat… 
2012
2012
Preclinical Development Evaluation of the Antitumor Effects and Mechanisms of PF 00299804 , a Pan-HER Inhibitor , Alone or in Combination with Chemotherapy or Targeted Agents in Gastric Cancer
Recently, HER2-directed treatment, such as trastuzumab, has shown clinical benefit in HER2-amplified gastric cancer. On the basis… 
2012
2012
Molecular Medicine in Practice Cotargeting MAPK and PI 3 K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer
There is an urgent need for the development of novel therapies to treat pancreatic cancer,which is among the most lethal of all… 
Review
2012
Review
2012
CellsMetastasis Initiated from Prostate Cancer Stem/Progenitor Loss and RAS/MAPK Activation Cooperate to Promote EMT Pten
PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in… 
2011
2011
Preclinical Development In Vivo Activity of Combined PI 3 K / mTOR and MEK Inhibition in a KrasG 12 D ; Pten Deletion Mouse Model of Ovarian Cancer
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is commonly dysregulated in human cancer, making it an attractive target for…