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PCDH10 gene

Known as: PCDH10, OL-PCDH, KIAA1400 
 
National Institutes of Health

Papers overview

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2017
2017
Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene
BACKGROUND Behavioral symptoms in individuals with autism spectrum disorder (ASD) have been attributed to abnormal neuronal… Expand
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Highly Cited
2016
Highly Cited
2016
MALAT1 long ncRNA promotes gastric cancer metastasis by suppressing PCDH10
EZH2, the catalytic component of polycomb repressive complex 2 (PRC2), is frequently overexpressed in human cancers and… Expand
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2016
2016
Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors
HOTAIR, a long non-coding RNA (lncRNA), plays a crucial role in tumor initiation and metastasis by interacting with the PRC2… Expand
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Highly Cited
2012
Highly Cited
2012
Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95
The activity-dependent transcription factor myocyte enhancer factor 2 (MEF2) induces excitatory synapse elimination in mouse… Expand
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2012
2012
Role of PCDH10 and its hypermethylation in human gastric cancer.
Epigenetic changes of genomic DNA are involved in the development and progression of many cancers. Aberrant methylation of CpG… Expand
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2012
2012
Frequent epigenetic silencing of PCDH10 by methylation in human colorectal cancer
PurposeAberrant DNA methylation is common in cancer cells. Epigenetic alterations resulting in the loss of tumor suppression gene… Expand
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2010
2010
High-resolution melting analysis of PCDH10 methylation levels in gastric, colorectal and pancreatic cancers.
Protocadherins are celladhesion molecules with 6 or 7 cadherin motifs in their extracellular domain and various cyotoplasmic… Expand
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Highly Cited
2009
Highly Cited
2009
Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer.
BACKGROUND & AIMS By using methylation-sensitive representational difference analysis, we identified protocadherin 10 (PCDH10), a… Expand
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Highly Cited
2009
Highly Cited
2009
Protocadherin PCDH10, involved in tumor progression, is a frequent and early target of promoter hypermethylation in cervical cancer.
Cervical cancer (CC) is the second most common cancer in women. Currently, no tractable molecular-based therapeutic targets exist… Expand
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Highly Cited
2006
Highly Cited
2006
Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation
Protocadherins constitute the largest subgroup in the cadherin superfamily of cell adhesion molecules. Their major functions are… Expand
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