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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis
TLDR
Emerging evidence indicates that epigenetic regulations and noncoding RNAs may play important roles in breast cancer development and may contribute to the heterogeneity and metastatic aspects of breast cancer, especially for triple-negative breast cancer. Expand
The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer
TLDR
UCHL1 exerts its tumor suppressive functions by inducing G0/G1 cell cycle arrest and apoptosis in breast tumorigenesis, requiring its deubiquitinase activity. Expand
Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and β-catenin signaling pathway.
TLDR
It is suggested that mangiferin might be used as an effective chemopreventive agent against breast cancer through modulation of MMP-7 and -9, and EMT, and inhibition of β-catenin pathway. Expand
Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells
TLDR
Increased CXCR7 expression was found in hepatocellular carcinoma tissues and high invasive potential HCC cell lines express high levels of CX CR7, and new insights are provided into the significance of CxCR7 in invasion and angiogenesis of HCC. Expand
Resilience and Quality of Life: Exploring the Mediator Role of Social Support in Patients with Breast Cancer
TLDR
Social support is essential for the development of resilience and the improvement of quality of life in Chinese patients with breast cancer and health professionals should provide appropriate guidelines to help patients seek effective support and enhance their resilience to improve theirquality of life after breast cancer. Expand
Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway.
TLDR
Results indicate that naringin could inhibit growth potential of TNBC cells by modulating β-catenin pathway, which suggests naring in might be used as a potential supplement for the prevention and treatment of breast cancer. Expand
miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGγ.
TLDR
The data indicate that miR-7-5p has a critical function through blocking REGγ in breast cancer cells, and that the knockdown of REGγ expression suppresses cell proliferation and induces apoptosis in vitro and in vivo. Expand
Cyclooxygenase-2 in tumor-associated macrophages promotes breast cancer cell survival by triggering a positive-feedback loop between macrophages and cancer cells
TLDR
The findings suggest that COX-2, functions as a key cancer promoting factor by triggering a positive-feedback loop between macrophages and cancer cells, which could be exploited for breast cancer prevention and therapy. Expand
Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia
TLDR
It is reported that influenza infection induced pulmonary IL‐27 production in a type I IFN‐α/β receptor (IFNAR) signalling‐dependent manner, which sensitized mice to secondary pneumococcal infection downstream of IFNAR pathway, thereby leading to enhanced neutrophil response during the early phase of host defence. Expand
Discordance and clinical significance of ER, PR, and HER2 status between primary breast cancer and synchronous axillary lymph node metastasis
TLDR
The determination of hormone receptors and HER2 status should be routinely performed in synchronous axillary nodal metastasis, together with primary tumor, to guide therapy management and evaluate the recurrent risk of primary invasive breast cancer patients with synchronousAxillary lymph node metastasis. Expand
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