FAQ

PAX3 gene

Known as: paired box 3, Paired Box Gene 3 (Waardenburg Syndrome 1) Gene, HUP2 
This gene plays a role in the transcriptional activation of target genes. It is involved in melanogenesis, neurogenesis and skeletal muscle… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2018
0102019922018

Related topics

Related topics

8 relations
ApoptosisBiologic DevelopmentHomo sapiensOrganogenesis
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Narrower (1)

PAX3 wt Allele

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
PAX3 gene
Apoptosis
dna binding
Homo sapiens
Organogenesis
Transcriptional Regulation

Papers overview

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2008
2008
Sequential actions of Pax3 and Pax7 drive xanthophore development in zebrafish neural crest.
The Pax3/7 gene family has a fundamental and conserved role during neural crest formation. In people, PAX3 mutation causes… (More)
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2001
2001
PAX3 is expressed in human melanomas and contributes to tumor cell survival.
Deregulated expression of the transcription factor PAX3 was observed previously in several tumors like rhabdomyosarcoma and Ewing… (More)
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Highly Cited
2000
Highly Cited
2000
Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome.
Waardenburg syndrome (WS) is an autosomal dominant disorder with an incidence of 1 in 40 000 that manifests with sensorineural… (More)
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Highly Cited
2000
Highly Cited
2000
Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3
Waardenburg syndrome (WS) is associated with neural crest-derived melanocyte deficiency caused by mutations in either one of… (More)
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2000
2000
Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR
The aberrant expression of the transcription factors PAX3 and PAX3/FKHR associated with rhabdomyosarcoma (RMS), solid tumors… (More)
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Highly Cited
1999
Highly Cited
1999
cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene
Alveolar rhabdomyosarcoma is an aggressive pediatric cancer of striated muscle characterized in 60% of cases by a t(2;13)(q35;q14… (More)
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1999
1999
PAX3 gene structure, alternative splicing and evolution.
PAX3 is a member of the paired box family of transcription factors that function during embryogenesis and cancer epigenesis… (More)
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Highly Cited
1998
Highly Cited
1998
Epistatic relationship between Waardenburg Syndrome genes MITF and PAX3
Waardenburg syndrome (WS) is a hereditary disorder that causes hypopigmentation and hearing impairment. Depending on additional… (More)
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Highly Cited
1995
Highly Cited
1995
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.
Alveolar rhabdomyosarcomas are pediatric solid tumors with a hallmark cytogenetic abnormality: translocation of chromosomes 2 and… (More)
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Highly Cited
1993
Highly Cited
1993
Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma
We have determined that PAX3 (found previously to be mutated in Waardenburg syndrome) is the chromosome 2 locus rearranged by the… (More)
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