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PAX3 gene

Known as: paired box 3, Paired Box Gene 3 (Waardenburg Syndrome 1) Gene, HUP2 
This gene plays a role in the transcriptional activation of target genes. It is involved in melanogenesis, neurogenesis and skeletal muscle… 
National Institutes of Health

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Related topics

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ApoptosisBiologic DevelopmentHomo sapiensOrganogenesis

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PAX3 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer.
The neurocristopathies encompass a spectrum of developmental disorders characterized by abnormalities of neural crest-derived… 
Highly Cited
2003
Highly Cited
2003
The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo.
Pax3 is a key transcription factor implicated in development and human disease. To dissect the role of Pax3 in myogenesis and… 
Review
2001
Review
2001
Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma
The chromosomal translocations t(2;13)(q35;q14) and t(1;13)(p36;q14) are characteristic of alveolar rhabdomyosarcoma, a pediatric… 
Highly Cited
2001
Highly Cited
2001
Microarray Analysis Detects Novel Pax3 Downstream Target Genes* 210
Pax3 is a transcription factor that is required for the development of embryonic neural tube, neural crest, and somatic… 
Highly Cited
2001
Highly Cited
2001
Pax3 Is Essential for Skeletal Myogenesis and the Expression of Six1 and Eya2*
Pax3 is a paired box transcription factor expressed during somitogenesis that has been implicated in initiating the expression of… 
Highly Cited
1999
Highly Cited
1999
The Pax3–FKHR oncoprotein is unresponsive to the Pax3‐associated repressor hDaxx
The Pax3–FKHR fusion protein is present in alveolar rhabdomyosarcoma and results from the t(2;13) (q35;q14) chromosomal… 
Highly Cited
1998
Highly Cited
1998
HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3
HIRA maps to the DiGeorge/velocardiofacial syndrome critical region (DGCR) at 22q11 (Refs 1,2) and encodes a WD40 repeat protein… 
Highly Cited
1996
Highly Cited
1996
Pax3 modulates expression of the c-Met receptor during limb muscle development.
Pax3 is a transcription factor whose expression has been used as a marker of myogenic precursor cells arising in the lateral… 
Highly Cited
1995
Highly Cited
1995
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3
Alveolar rhabdomyosarcomas are pediatric solid tumors with a hallmark cytogenetic abnormality: translocation of chromosomes 2 and… 
Highly Cited
1993
Highly Cited
1993
Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.
Alveolar rhabdomyosarcoma, a malignant tumor of skeletal muscle, is characterized by a chromosomal translocation, t(2;13)(q35;q14… 
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