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PAX3 gene
Known as:
paired box 3
, Paired Box Gene 3 (Waardenburg Syndrome 1) Gene
, HUP2
Â
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This gene plays a role in the transcriptional activation of target genes. It is involved in melanogenesis, neurogenesis and skeletal muscle…Â
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National Institutes of Health
Topic mentions per year
Topic mentions per year
1992-2018
0
10
20
1992
2018
Related topics
Related topics
8 relations
Apoptosis
Biologic Development
Homo sapiens
Organogenesis
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Narrower (1)
PAX3 wt Allele
Related mentions per year
Related mentions per year
1937-2018
1940
1960
1980
2000
2020
PAX3 gene
Apoptosis
dna binding
Homo sapiens
Organogenesis
Transcriptional Regulation
Papers overview
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2008
2008
Sequential actions of Pax3 and Pax7 drive xanthophore development in zebrafish neural crest.
James E N Minchin
,
Simon M Hughes
Developmental biology
2008
The Pax3/7 gene family has a fundamental and conserved role during neural crest formation. In people, PAX3 mutation causes…Â
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2001
2001
PAX3 is expressed in human melanomas and contributes to tumor cell survival.
Francesco Scholl
,
Jivko Kamarashev
,
O V Murmann
,
Ralf Geertsen
,
Russell Dummer
,
Barbara Schaefer
Cancer research
2001
Deregulated expression of the transcription factor PAX3 was observed previously in several tumors like rhabdomyosarcoma and Ewing…Â
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Highly Cited
2000
Highly Cited
2000
Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome.
Nadége Bondurand
,
Véronique Pingault
,
+5 authors
M. Goossens
Human molecular genetics
2000
Waardenburg syndrome (WS) is an autosomal dominant disorder with an incidence of 1 in 40 000 that manifests with sensorineural…Â
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Highly Cited
2000
Highly Cited
2000
Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3
S. Brian Potterf
,
Minao Furumura
,
Karen Joyce Dunn
,
Heinz Arnheiter
,
William J. Pavan
Human Genetics
2000
Waardenburg syndrome (WS) is associated with neural crest-derived melanocyte deficiency caused by mutations in either one of…Â
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2000
2000
Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR
Christiane M Margue
,
Michele Bernasconi
,
Frederic G. Barr
,
Beat W. Schäfer
Oncogene
2000
The aberrant expression of the transcription factors PAX3 and PAX3/FKHR associated with rhabdomyosarcoma (RMS), solid tumors…Â
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Highly Cited
1999
Highly Cited
1999
cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene
Javed Khan
,
Michael L. Bittner
,
+7 authors
Paul S. Meltzer
Nature Genetics
1999
Alveolar rhabdomyosarcoma is an aggressive pediatric cancer of striated muscle characterized in 60% of cases by a t(2;13)(q35;q14…Â
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1999
1999
PAX3 gene structure, alternative splicing and evolution.
Tom Barber
,
Mary C. Barber
,
Timothy E Cloutier
,
Thomas B Friedman
Gene
1999
PAX3 is a member of the paired box family of transcription factors that function during embryogenesis and cancer epigenesis…Â
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Highly Cited
1998
Highly Cited
1998
Epistatic relationship between Waardenburg Syndrome genes MITF and PAX3
Atsushi Watanabe
,
Kazuhisa Takeda
,
Barbara Ploplis
,
Masayoshi Tachibana
Nature Genetics
1998
Waardenburg syndrome (WS) is a hereditary disorder that causes hypopigmentation and hearing impairment. Depending on additional…Â
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Highly Cited
1995
Highly Cited
1995
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.
W J Fredericks
,
Naomi Bruce Galili
,
+4 authors
Frank J. Rauscher
Molecular and cellular biology
1995
Alveolar rhabdomyosarcomas are pediatric solid tumors with a hallmark cytogenetic abnormality: translocation of chromosomes 2 and…Â
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Highly Cited
1993
Highly Cited
1993
Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma
Frederic G. Barr
,
Naomi Bruce Galili
,
John Holick
,
Jaclyn A Biegel
,
Giovanni Giacomo Rovera
,
Beverly S Emanuel
Nature Genetics
1993
We have determined that PAX3 (found previously to be mutated in Waardenburg syndrome) is the chromosome 2 locus rearranged by the…Â
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