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PAX3 gene

Known as: paired box 3, Paired Box Gene 3 (Waardenburg Syndrome 1) Gene, HUP2 
This gene plays a role in the transcriptional activation of target genes. It is involved in melanogenesis, neurogenesis and skeletal muscle… 
National Institutes of Health

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Related topics

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ApoptosisBiologic DevelopmentHomo sapiensOrganogenesis

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PAX3 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Loss of MicroRNA‐489‐3p promotes osteosarcoma metastasis by activating PAX3‐MET pathway
Osteosarcoma (OS) remains one deadly disease for many affected patients. MicroRNAs (miRNAs) are thought to have an important role… 
2011
2011
Differential PAX3 functions in normal skin melanocytes and melanoma cells.
2011
2011
Identification of serines 201 and 209 as sites of Pax3 phosphorylation and the altered phosphorylation status of Pax3-FOXO1 during early myogenic differentiation.
Highly Cited
2004
Highly Cited
2004
Analysis of the transforming and growth suppressive activities of the PAX3-FKHR oncoprotein
The 2;13 chromosomal translocation occurs in most cases of the cancer alveolar rhabdomyosarcoma (ARMS), and juxtaposes the genes… 
Highly Cited
2002
Highly Cited
2002
Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest.
The neural crest plays a crucial part in cardiac development. Cells of the cardiac subpopulation of cranial neural crest migrate… 
2002
2002
Pax3 regulates morphogenetic cell behavior in vitro coincident with activation of a PCP/non-canonical Wnt-signaling cascade.
Mutations to Pax3 and other Pax family genes in both mice and humans result in numerous tissue-specific morphological defects… 
2002
2002
Pax3 induces cell aggregation and regulates phenotypic mesenchymal-epithelial interconversion.
Paired box-containing transcription factors play fundamental roles in pattern formation during embryonic development of diverse… 
Review
2001
Review
2001
Pax3 and the splotch mutations: structure, function, and relationship to teratogenesis, including gene-chemical interactions.
The current review focuses on the malformations resulting from mutations in Pax3 and the interactions of Pax3 mutations with… 
Review
1998
Review
1998
The role of Pax3 and Pax7 in development and cancer.
Pax genes consist of a family of transcription factors that are essentially required for the genesis of a variety of tissues and… 
Highly Cited
1994
Highly Cited
1994
PAX3 gene structure and mutations: close analogies between Waardenburg syndrome and the Splotch mouse.
The human PAX3 gene contains a paired box and a paired-type homeobox, and is believed to play a role in pattern formation in the… 
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