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PARK2 protein, human

Known as: Parkinson disease (autosomal recessive, juvenile) 2, parkin, human, E3 Ubiquitin-Protein Ligase Parkin, Parkinson Disease Protein 2 
E3 ubiquitin-protein ligase parkin (465 aa, ~52 kDa) is encoded by the human PARK2 gene. This protein may play a role in the ubiquitination of… 
National Institutes of Health

Related topics

Related topics

11 relations
Cell DeathEnzyme GeneHomo sapiensLigase Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Mechanism of phospho-ubiquitin induced PARKIN activation
The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal… 
Highly Cited
2012
Highly Cited
2012
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria
Dysfunction of PINK1, a mitochondrial Ser/Thr kinase, causes familial Parkinson's disease (PD). Recent studies have revealed that… 
Highly Cited
2012
Highly Cited
2012
Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
Mitochondria can be degraded by autophagy in a process termed mitophagy. The Parkinson-disease-associated ubiquitin ligase Parkin… 
Highly Cited
2011
Highly Cited
2011
PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
Highly Cited
2011
Highly Cited
2011
Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1
Autophagy-dependent mitochondrial turnover in response to cellular stress is necessary for maintaining cellular homeostasis… 
Highly Cited
2010
Highly Cited
2010
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
PINK1 and Parkin were first identified as the causal genes responsible for familial forms of early‐onset Parkinson’s disease (PD… 
Highly Cited
2010
Highly Cited
2010
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
Mitochondrial genomes with deleterious mutations can replicate in cells along with wild-type genomes in a state of heteroplasmy… 
Highly Cited
2010
Highly Cited
2010
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
Mitochondrial dysfunction is an early sign of many neurodegenerative diseases. Very recently, two Parkinson disease (PD… 
Highly Cited
2009
Highly Cited
2009
Parkin-induced mitophagy in the pathogenesis of Parkinson disease
Knockout of the ubiquitin ligase Parkin, the gene product of the Parkinson associated Park2, leads to loss of mitochondrial… 
Highly Cited
2008
Highly Cited
2008
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.
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