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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
It is demonstrated that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing.
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Methods in Mammalian Autophagy Research
Autophagy fights disease through cellular self-digestion
Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.
Autophagy: Renovation of Cells and Tissues
The role of Atg proteins in autophagosome formation.
- N. Mizushima, T. Yoshimori, Y. Ohsumi
- Biology, ChemistryAnnual review of cell and developmental biology
- 10 October 2011
The molecular mechanism of autophagosome formation is described with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagous membrane membrane.
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
It is demonstrated that necroptosis contributes to delayed mouse ischemic brain injury in vivo through a mechanism distinct from that of apoptosis and offers a new therapeutic target for stroke with an extended window for neuroprotection.
Autophagy: process and function.
- N. Mizushima
- Biology, ChemistryGenes & development
- 15 November 2007
In this review, the process of autophagy is summarized, and the role of autophileagy is discussed in a process-based manner.
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker.
- N. Mizushima, A. Yamamoto, M. Matsui, T. Yoshimori, Y. Ohsumi
- BiologyMolecular biology of the cell
- 29 December 2003
The results suggest that the regulation of autophagy is organ dependent and the role of Aut7/Apg8 is not restricted to the starvation response, and this transgenic mouse model is a useful tool to study mammalian autophagic regulation.
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.