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PAK4/NAMPT Inhibitor KPT-9274
Known as:
KCP-9274
, KPT-9274
An orally bioavailable inhibitor of both the serine/threonine kinase P21-activated kinase 4 (PAK4) and the nicotinamide adenine dinucleotide (NAD…
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National Institutes of Health
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1 relation
NCIt Antineoplastic Agent Terminology
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
KPT-9274. First-in-class dual inhibitor of NAMPT and PAK-4, Treatment of advanced solid malignancies, Treatment of non-Hodgkin's lymphoma
D. Cho
2018
Corpus ID: 58387456
2018
2018
NAMPT Inhibitor KPT-9274 Selectively Targets Self-Renewal Capacity in Acute Myeloid Leukemia
Shaneice R Mitchell
,
N. Grieselhuber
,
+15 authors
J. Byrd
Blood
2018
Corpus ID: 92007250
Acute Myeloid Leukemia (AML) is a heterogeneous disease that is characterized by an accumulation of neoplastic myeloid…
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2017
2017
Abstract LB-308: KPT-9274 inhibits cellular NAD and synergizes with doxorubicin to treat dogs with lymphoma
C. London
,
Megan E Brown
,
+8 authors
E. Baloglu
2017
Corpus ID: 80495380
Nicotinamide adenine dinucleotide (NAD), an essential metabolite and cofactor of several biological processes (e.g. genomic…
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2017
2017
Multiple myeloma cells sent "PAKing"!
P. Neri
,
N. Bahlis
Blood
2017
Corpus ID: 206951818
In this issue of Blood, Fulciniti et al report on the role of p21-activated kinase 4 (PAK4), a member of the p21-activated…
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2017
2017
NAMPT inhibitor KPT-9274 as an alternative treatment for Acute Myeloid Leukemia
Yerdanos Asmelash
2017
Corpus ID: 80476346
KPT-9274 Decreases Colony Formation in AML Leukemic Patient Cell Lines • Acute Myeloid Leukemia (AML) is a cancer characterized…
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2016
2016
Abstract 1864:In vivoefficacy of the PAK4 allosteric modulator KPT-9274 against a triple-negative breast cancer model
Chetan K Rane
,
W. Senapedis
,
E. Baloglu
,
S. Shacham
,
A. Minden
2016
Corpus ID: 57500459
The p21-activated kinases (PAK) belong to a family of serine threonine kinases that promote cell survival and play an important…
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2016
2016
Abstract 4827: Co-administration of nicotinic acid (NA) enhances the therapeutic index of KPT-9274 in cancer cells
W. Senapedis
,
C. Argueta
,
Y. Landesman
,
Margaret S. Lee
,
S. Shacham
,
Erkan Balolgu
2016
Corpus ID: 79170458
We have previously described the PAK4 allosteric modulators (PAMs), KPT-7523 and KPT-9274, as potent anti-cancer small molecules…
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2016
2016
Abstract 3799: The PAK4 allosteric modulator (KPT-9274) attenuates the growth of renal cell carcinoma
R. Weiss
,
Omran Abu Aboud
,
E. Baloglu
,
W. Senapedis
,
S. Shacham
2016
Corpus ID: 78227640
Renal cell carcinoma (RCC) is an increasingly prevalent cancer type that is frequently asymptomatic on presentation and is…
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2015
2015
Abstract 2644: Inhibition of PAK4 attenuates renal cell carcinoma (RCC) growth
Omran Abu Aboud
,
W. Senapedis
,
Y. Landesman
,
E. Baloglu
,
R. Weiss
2015
Corpus ID: 78683515
Renal cell carcinoma (RCC) is an increasingly prevalent cancer type that is frequently asymptomatic on presentation and is…
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2015
2015
In Vitro and In Vivo Anti-Leukemic Effects of KPT-9274, a Reported PAK4 Allosteric Modulator, in Acute Myeloid Leukemia: Promising Results Justifying Further Development in This Disease
Shaneice R Mitchell
,
S. Orwick
,
+16 authors
J. Byrd
2015
Corpus ID: 89364008
Acute Myeloid Leukemia (AML) is the most common adult acute leukemia and is characterized by numerous driver mutations and/or…
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