P-glycoprotein Inhibitor

Known as: P-gp inhibitor 
Any compound or agent that acts to prevent the activity of P-glycoprotein.
National Institutes of Health

Papers overview

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2019
2019
Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior.
Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly specialized brain microvascular… (More)
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2017
2017
Co-delivery of docetaxel and verapamil by reduction-sensitive PEG-PLGA-SS-DTX conjugate micelles to reverse the multi-drug resistance of breast cancer.
The clinical usage of docetaxel (DTX) has been blocked in the clinic because of its poor solubility and tumour multi-drug… (More)
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2016
2016
Curcumin-docetaxel co-loaded nanosuspension for enhanced anti-breast cancer activity.
PURPOSE A curcumin-docetaxel co-loaded nanosuspension with increased anti-breast cancer activity was developed. Curcumin is a… (More)
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2015
2015
Novel dietary lipid-based self-nanoemulsifying drug delivery systems of paclitaxel with p-gp inhibitor: implications on cytotoxicity and biopharmaceutical performance.
OBJECTIVES This work describes the development and characterization of novel self-nanoemulsifying drug delivery systems (SNEDDS… (More)
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2008
2008
Intestinal Absorption Mechanisms of Prenylated Flavonoids Present in the Heat-Processed Epimedium koreanum Nakai (Yin Yanghuo)
The purpose is to determine absorption mechanism of five bioactive prenylated flavonoids (baohuoside I, icariin, epimedine A, B… (More)
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Highly Cited
2007
Highly Cited
2007
Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
Generation and deposition of the amyloid beta (Abeta) peptide following proteolytic processing of the amyloid precursor protein… (More)
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2007
2007
Minocycline and riluzole brain disposition: interactions with p-glycoprotein at the blood-brain barrier.
Amyotrophic lateral sclerosis is a neurodegenerative fatal disease. The only drug recognized to increase the survival time is… (More)
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2006
2006
Role of P-glycoprotein in tissue uptake of indinavir in rat.
The effect of p-glycoprotein inhibition on tissue distribution of indinavir, an anti-HIV (human immunodeficiency virus) protease… (More)
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2004
2004
Toxicity of Quinacrine Can Be Reduced By Co-Administration of P-Glycoprotein Inhibitor in Sporadic Creutzfeldt-Jakob Disease
1. Recent publication has suggested that quinacrine may be a candidate for treatment of Creutzfeldt-Jakob disease (CJD). But… (More)
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1995
1995
Effect of the p-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving rats.
The p-glycoprotein is a transmembrane efflux transporter found on the luminal side of the capillary endothelial cells that… (More)
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