Otic placode

Known as: Otic Placodes 
A patch of thickened ectoderm alongside the hindbrain in the early embryo that will give rise to the otic pit.
National Institutes of Health

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Embryonic ear

Papers overview

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Highly Cited
2006
Highly Cited
2006
Wnt signals mediate a fate decision between otic placode and epidermis.
The otic placode, the anlagen of the inner ear, develops from an ectodermal field characterized by expression of the… (More)
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2005
2005
Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode.
Vertebrate Pax2 and Pax8 proteins are closely related transcription factors hypothesized to regulate early aspects of inner ear… (More)
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2004
2004
A direct role for Fgf but not Wnt in otic placode induction.
Induction of the otic placode, which gives rise to all tissues comprising the inner ear, is a fundamental aspect of vertebrate… (More)
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Highly Cited
2003
Highly Cited
2003
Fgf3 and Fgf10 are required for mouse otic placode induction.
The inner ear, which contains the sensory organs specialised for audition and balance, develops from an ectodermal placode… (More)
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Highly Cited
2003
Highly Cited
2003
Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification.
The vertebrate inner ear develops from the otic placode, an ectodermal thickening that forms adjacent to the presumptive… (More)
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Highly Cited
2002
Highly Cited
2002
Extensive cell movements accompany formation of the otic placode.
During development, the vertebrate inner ear arises from the otic placode, a thickened portion of the ectoderm next to the… (More)
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Highly Cited
2002
Highly Cited
2002
Fgf3 and Fgf8 are required together for formation of the otic placode and vesicle.
Fgf3 has long been implicated in otic placode induction and early development of the otocyst; however, the results of experiments… (More)
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Highly Cited
2002
Highly Cited
2002
Fgf8 and Fgf3 are required for zebrafish ear placode induction, maintenance and inner ear patterning
The vertebrate inner ear develops from initially 'simple' ectodermal placode and vesicle stages into the complex three… (More)
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Highly Cited
2001
Highly Cited
2001
Zebrafish fgf3 and fgf8 encode redundant functions required for otic placode induction.
Members of the fibroblast growth factor (FGF) family of peptide ligands have been implicated in otic placode induction in several… (More)
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Highly Cited
2000
Highly Cited
2000
Competence, specification and commitment in otic placode induction.
The inner ear is induced from cranial ectoderm adjacent to the hindbrain. Despite almost a century of study, the molecular… (More)
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