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Otenabant

Known as: 1-(8-(2-Chlorophenyl)-9-(4-Chlorophenyl)-9H-Purin-6-yl)-4-(Ethylamino)Piperidine-4-Carboxamide, 4-Piperidinecarboxamide, 1-(8-(2-Chlorophenyl)-9-(4-Chlorophenyl)-9H-Purin-6-yl)-4- (Ethylamino)- 
National Institutes of Health

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CP-945,598

Papers overview

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Review
2019
Review
2019
Advances in the Understanding of the Cannabinoid Receptor 1 - Focusing on the Inverse Agonists Interactions
BACKGROUND Cannabinoid Receptor 1 (CB1) is a membrane protein prevalent in the central nervous system, whose crystallographic… 
2019
2019
Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor.
Antagonists of peripheral type 1 cannabinoid receptors (CB1) have potential utility in the treatment of various diseases… 
2017
2017
Pharmacological comparison of traditional and non-traditional cannabinoid receptor 1 blockers in rodent models in vivo
2015
2015
(4-(Bis(4-Fluorophenyl)Methyl)Piperazin-1-yl)(Cyclohexyl)Methanone Hydrochloride (LDK1229): A New Cannabinoid CB1 Receptor Inverse Agonist from the Class of Benzhydryl Piperazine Analogs
Some inverse agonists of cannabinoid receptor type 1 (CB1) have been demonstrated to be anorectic antiobesity drug candidates… 
2014
2014
Relative Contributions of Cytochrome CYP 3 A 4 Versus CYP 3 A 5 for CYP 3 A-Cleared Drugs Assessed In Vitro Using a CYP 3 A 4-Selective Inactivator ( CYP 3 cide ) s
Metabolism by cytochrome P4503A (CYP3A) is the most prevalent clearance pathway for drugs. Designation of metabolism by CYP3A… 
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