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α7 Nicotinic acetylcholine receptors and their role in cognition
TLDR
This review attempts to summarise the experimental findings that support the role of one of the most distributed receptor subtypes, the α7 nAChRs, and particularly focus on its procognitive effects following receptor activation, and demonstrates with increasing confidence its promise as a molecular target in future pharmacotherapy to prevent cognitive decline in various types of dementia. Expand
Effect of 5-HT5A antagonists in animal models of schizophrenia, anxiety and depression
TLDR
A-843277 showed an antidepressant-like property in the FST, but its immobility-reducing effect may also be a consequence of abdominal irritation, and further investigations are required to define the therapeutic potential of 5-HT5A receptor ligands in anxiety, depression and schizophrenia models. Expand
Shock priming enhances the efficacy of SSRIs in the foot shock-induced ultrasonic vocalization test
TLDR
It is shown that priming has a major impact on the effectiveness of SSRIs in the USV test, and the three test protocols applied in this study have different predictive and face validity. Expand
Interactions of CB1 and mGlu5 receptor antagonists in food intake, anxiety and memory models in rats
TLDR
By combination of CB(1) and mGluR5 antagonism, anxiety related side effects might be attenuated, appetite suppression maintained, nevertheless, the possible emergence of unwanted memory impairments can overshadow its therapeutic success. Expand
Following of aging process in a new motor skill learning model, “pot jumping” in rats
TLDR
The method is appropriate to study the development of motor learning and to follow its age-dependent changes and may also serve as an assay for testing potential drugs for improving motor skills and/or procedural memory. Expand
Establishment of a rodent cooperation assay as a model of social cognition.
TLDR
The newly developed rat cooperation model is quick and has sufficiently high throughput, therefore it may be used in the drug development of putative social cognitive enhancer compounds. Expand
Selegiline reduces adiposity induced by high‐fat, high‐sucrose diet in male rats
TLDR
Effect of a widely used, selective MAO‐B inhibitor, selegiline, on metabolic parameters in a rat model of diet‐induced obesity is assessed. Expand
Translational Difficulties in Querying Rats on “Orientation”
TLDR
The observed lack of time discrimination may source from an evolutionary built in mechanism characteristic for the rat species or this ability may have only been lost in laboratory rats. Expand
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