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OspA protein

Known as: OspA vaccine, outer surface protein A 
National Institutes of Health

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4 relations

Broader (4)

Bacterial Outer Membrane ProteinsBacterial VaccinesLipoproteinsSurface Antigens

Papers overview

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Highly Cited
2006
Highly Cited
2006
Protective efficacy of an oral vaccine to reduce carriage of Borrelia burgdorferi (strain N40) in mouse and tick reservoirs.
2003
2003
Unfolding mechanics of multiple OspA substructures investigated with single molecule force spectroscopy.
Highly Cited
1997
Highly Cited
1997
Borrelia burgdorferi outer surface protein A (OspA) activates and primes human neutrophils.
Lyme disease is caused by infection with the spirochete Borrelia burgdorferi and is characterized by bacterial persistence and… 
1997
1997
OspA lipoprotein of Borrelia burgdorferi is a mucosal immunogen and adjuvant.
Highly Cited
1996
Highly Cited
1996
Borrelia burgdorferi outer membrane protein A induces nuclear translocation of nuclear factor-kappa B and inflammatory activation in human endothelial cells.
Lyme disease is caused by infection with Borrelia burgdorferi, and is characterized by bacterial persistence and inflammation in… 
Highly Cited
1995
Highly Cited
1995
Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi
Outer surface protein A (OspA), which is abundantly expressed in cultured Borrelia burgdorferi, appears to be down-regulated or… 
Highly Cited
1995
Highly Cited
1995
Incomplete protection of hamsters vaccinated with unlipidated OspA from Borrelia burgdorferi infection is associated with low levels of antibody to an epitope defined by mAb LA-2.
Highly Cited
1995
Highly Cited
1995
Early and late antibody responses to full-length and truncated constructs of outer surface protein A of Borrelia burgdorferi in Lyme disease
The immunoglobulin G (IgG) antibody response to outer surface protein A (OspA) of Borrelia burgdorferi has been reported to occur… 
Highly Cited
1993
Highly Cited
1993
Protective immunity is induced by a Borrelia burgdorferi mutant that lacks OspA and OspB
A mutant of virulent Borrelia burgdorferi 297 was apparently selected for by long-term storage at 5 degrees C. This mutant was… 
1991
1991
Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA.
Mice immunized with recombinant outer surface protein A (OspA) in Freund's adjuvant or with intraperitoneal injections of live… 
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