Org 31710

Antiprogestins have been largely utilized in reproductive medicine, yet their repositioning for oncologic use is rapidly emerging… (More)

Progesterone (P4) antagonizes estradiol (E2) in synaptic remodeling in the hippocampus during the rat estrous cycle. To further… (More)

ORG 31710 and ORG 33628 were used in studies aiming to control vaginal bleeding in combination with progestagen-only… (More)

Progesterone-receptor (PR) stimulation promotes survival in rat and human periovulatory granulosa cells. To investigate the… (More)

OBJECTIVE To investigate if progesterone receptor (PR)-mediated effects are involved in regulating the susceptibility to… (More)

Org 31710 and Org 33628 are two highly selective progesterone receptor modulators (PRMs) with respect to their anti… (More)

Progesterone (P) is one of several local mediators in the ovulatory cascade in the rat. The precise mechanisms of action for P in… (More)

To investigate ovulation, an in vitro model with cultured mouse follicles was developed and compared with an in vivo ovulation… (More)

The safety and tolerability as well as pharmacokinetics of a new selective antiprogestagen, Org 31710, were studied after oral… (More)

Org 31710 and Org 31806 are new antiprogestagens. These compounds were tested for their binding affinity to various steroid… (More)