FAQ

Orazamide

Known as: AICA orotate, 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, Compd. With 5-amino-1H-imidazole-4-carboxamide (1:1), Dihydrate, 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid cpd with 5-amino-1H-imidazole-4-carboxamide 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1959-2017
0102019592017

Related topics

Related topics

2 relations

Narrower (1)

Aicamine

Broader (1)

Aminoimidazole Carboxamide

Related mentions per year

Related mentions per year

1959-2018
1960198020002020
Orazamide
Aminoimidazole Carboxamide
Aicamine

Papers overview

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Highly Cited
2003
Highly Cited
2003
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
BACKGROUND The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master… (More)
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Highly Cited
2003
Highly Cited
2003
AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase.
We have recently shown that conditions known to activate AMP-activated protein kinase (AMPK) in primary beta-cells can trigger… (More)
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Highly Cited
2002
Highly Cited
2002
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism.
Metformin, a drug widely used to treat type 2 diabetes, was recently shown to activate the AMP-activated protein kinase (AMPK) in… (More)
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Highly Cited
2002
Highly Cited
2002
Activation of AMP-Activated Protein Kinase Leads to the Phosphorylation of Elongation Factor 2 and an Inhibition of Protein Synthesis
Protein synthesis, in particular peptide-chain elongation, consumes cellular energy. Anoxia activates AMP-activated protein… (More)
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Highly Cited
2002
Highly Cited
2002
Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle.
5'-AMP-activated protein kinase (AMPK) functions as a metabolic switch in mammalian cells and can be artificially activated by 5… (More)
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Highly Cited
2002
Highly Cited
2002
Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells.
Stimulation of AMP-activated protein kinase (AMPK) in skeletal muscle has been correlated with an increase in glucose transport… (More)
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Highly Cited
1999
Highly Cited
1999
5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle.
It has previously been reported that exercise causes an increase in glucose uptake in skeletal muscle and also an increase in 5… (More)
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Highly Cited
1999
Highly Cited
1999
AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.
AMP-activated kinase (AMPK) is activated in response to metabolic stresses that deplete cellular ATP, and in both liver and… (More)
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Highly Cited
1998
Highly Cited
1998
AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.
The role of the AMP-activated protein kinase (AMPK) cascade in the glucose-sensitive pancreatic beta cell lines HIT-T15 and INS-1… (More)
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Highly Cited
1997
Highly Cited
1997
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle.
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) has previously been reported to be taken up into cells and phosphorylated… (More)
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