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Oncolytic HSV-1 rRp450

Known as: rRp450 
A gene therapy agent containing an attenuated, replication-competent, genetically engineered mutant form of the Herpes simplex virus 1 (HSV-1) strain… Expand
National Institutes of Health

Papers overview

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2018
2018
Ewing sarcoma is a highly aggressive cancer that promotes the infiltration and activation of pro-tumor M2-like macrophages… Expand
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2017
2017
Pediatric brain tumors including medulloblastoma and atypical teratoid/rhabdoid tumor are associated with significant mortality… Expand
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2008
2008
Oncolytic herpes simplex virus (oHSV) mutants are under development as anticancer therapeutics. One such vector, rRp450, is ICP6… Expand
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2002
2002
BACKGROUND Herpes simplex virus 1 (HSV-1) infection of cancer cells results in viral replication with cell destruction and… Expand
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2001
2001
rRp450 is an oncolytic herpesvirus that expresses the CYP2B1 cDNA, responsible for bioconverting cyclophosphamide (CPA) into the… Expand
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2001
2001
Abstract Purpose: To test the in vitro efficacy of the chemotherapeutic alkylating agent prodrug 4-ipomeanol (4-IM) combined with… Expand
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Highly Cited
2000
Highly Cited
2000
Cellular delivery of a replication-conditional herpes simplex virus type 1 (HSV-1) vector provides a means for gene therapy of… Expand
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Highly Cited
2000
Highly Cited
2000
Herpes simplex virus type 1 (HSV-1) replication within tumors can mediate tumor regression (oncolysis). The genetically… Expand
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Highly Cited
1999
Highly Cited
1999
Multimodal therapy is generally more effective than single-agent treatment for cancer. rRp450 is an engineered herpes simplex… Expand
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