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Treatment of intrahepatic malignancy with radiofrequency ablation
The purpose of the current study was to assess technique safety, determine the extent and evolution of induced cellular damage, and correlate the observed pathologic effects with radiologic studies. Expand
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.
In an analysis of frozen tissue specimens, IDH1 mutation was associated with highly elevated tissue levels of the enzymatic product 2-hydroxyglutarate, defining a specific metabolic abnormality in this largely incurable type of gastrointestinal cancer and present a potentially new target for therapy. Expand
Surgical management of phyllodes tumors.
Phyllodes tumors mimic fibroadenomas and are often excised with close margins, and primary excision or reexcision with a 1-cm margin is recommended. Expand
Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis.
The EGF gene polymorphism genotype is associated with risk for development of hepatocellular carcinoma in liver cirrhosis through modulation of EGF levels through inhibition fragment-length polymorphism. Expand
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma
Data suggest that EGFR inhibition using Food and Drug Administration‐approved inhibitors provides a promising therapeutic approach for reduction of fibrogenesis and prevention of HCC in high‐risk cirrhosis patients who can be identified and monitored by gene expression signatures. Expand
Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells.
It is suggested that epithelial-to-mesenchymal transition predicts HCC sensitivity to EGFR-targeted therapies and that ILK is a novel target to overcome HCC resistance to EG FR inhibition. Expand
Multimodality management of Merkel cell carcinoma.
Merkel cell carcinoma is an aggressive dermal cancer with frequent nodal metastases; truncal tumors have the worst prognosis, but remission is possible with multimodality therapy. Expand
Percutaneous radiofrequency tissue ablation: does perfusion-mediated tissue cooling limit coagulation necrosis?
- S. Goldberg, P. Hahn, +6 authors G. Gazelle
- Journal of vascular and interventional radiology…
Reduction of blood flow during RF application increases coagulation in both an animal model and human liver metastases and reduces coagulated necrosis achievable with RF ablation. Expand
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver
It is shown that robust signatures of ECM proteins characteristic of each tissue, normal and malignant, can be defined using relatively small samples from small numbers of patients, and offer promise for development of diagnostic and prognostic signatures of metastatic potential of colon tumors. Expand
Prognosis and survival in patients with gastrointestinal tract carcinoid tumors.
Gastrointestinal tract carcinoid tumors have a nonspecific clinical presentation, except in the case of the carcinoid syndrome, and age, tumor size, depth, and location were significant predictors of metastases. Expand